Hello, I am looking for someone to write an essay on What is the current status of clinical gene therapy trials for Chronic Granulomatous Disorder. It needs to be at least 1500 words.

ests that the disease is present in ‘one in 250,000’ infants at birth, but the symptoms become evident only when the child reaches a few months of age (Assari 2006: 6). Only 21% of patients have survived the disease beyond the age of 7 previously, whereas the recent trends show improvement in the survival rates because of the ‘advancement in treatments’ (Assari 2006: 6). On the other hand, the disease can rarely occur in adults, and therefore, if someone has the problem of ‘recurrent infections’, it will be advisable to subject such individuals to an evaluation, irrespective of the age factor (Chung, Cyr & Ellis 2013: 2).

Gene therapy, which is the intervention in a disease or disorder through introducing genes into the affected cells to set right the impacts of ‘specific gene mutations’, is one of the methods used in the treatment of CGD (Dugal & Chaudhary 2012: 4). However, evidence suggests that in order for the treatment to be effective, the appropriate gene will have to be incorporated into the target cell ‘specifically, efficiently and stably’ (Dugal & Chaudhary 2012: 4). On the other hand, it is also necessary to use the most appropriate vector for the introduction of the gene or gene delivery into the human cell. Research studies have identified lentiviral vectors (LVs) to be one of the effective and the ‘most widely used’ vectors in gene therapy (Dugal & Chaudhary 2012: 4). A study conducted by Assari (2006: 6) on mice found that gene therapy, using recombinant retroviral vectors, is an effective treatment for the reconstruction of normal neutrophils and in building ‘resistance to pathogens’ such as Aspergillus. The author also contends that gene therapy, using retroviral vectors in two humans, has produced ‘encouraging results’ where both of them have attained remarkable levels of gene corrected cells and their clinical conditions show good improvement (Assari 2006: 6). Studies further substantiate the fact that gene

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Hello, I am looking for someone to write an essay on What is the best solution to preventing deaths from drunk driving this is a(problem solution). It needs to be at least 750 words.

To start with, drivers who drive under alcohol influence have impaired driving skills. According to Duke University, drunk drivers show deviations from pure rational decision making (4). Driving under influence of alcohol makes many people fail to obey the traffic rules accordingly or even fail to see the road signs at all. This is because many of those drivers may have taken the alcohol for fun or out of stress. Those who consume the alcohol for the fun bit of it may start exercising funny driving habits like driving with loud music in the vehicles just for fun but, loud music can cause obstruction to the driver leading to accident. On the other hand, drivers who take alcohol as a way of relieving stress can unknowingly drive the vehicles at very high or extremely low speeds that can obstruct other road users leading to accident.

Secondly, the road fatalities that result from drunk driving are alarmingly high calling for attention to solve the problem. Considering the number of road trips taken by people while driving under alcohol influence, the increased road fatalities are inevitable. According to Mothers Against Drunk Driving, “one out of every two thousand trips” are taken by drivers under alcoholic influence in America (1). This indicates the high probability of having road accidents caused by drunk drivers. Further, Mothers Against Drunk Driving state that someone gets killed in a drunk driving accident on an average of 53 minutes (1). The large numbers of deaths resulting from drunk driving indicate the seriousness of the problem to the society.

However, despite the seriousness of the problem, there exists a viable solution that when implemented could result into zero alcohol related accidents. Incorporation of technology to assist deter drunk drivers from driving vehicles can minimize if not end the problem. Use of alcohol detection gadgets by police on road patrol and

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Hello, I am looking for someone to write an essay on What is happiness to you. It needs to be at least 1000 words.

onio Rangel in 2008, money increases happiness as the people with a higher expense and expenditure lived a more happy life as compared to those who wanted to save cost. The group taking expensive wine was happier compared to the group taking less expensive wine. This means that happiness is all about money and if one spends more on someone they care for, they will be happy. Most people treasure good and expensive things that can only be bought with money in the materialistic world we live in today. There are some many destitute families in the world mostly in the developing countries, through charity these families can be helped using money thus making them happy. Happiness is based on what one acquires and achieves, hence money is happiness as it enables people acquire what they want.

In addition, happiness can be hinged on having good relationship with members of the family and the community as well. Family is a main contributing factor for one to be happy, as through the it, one is able to get solace in times of grief. Family provides some form of emotional support to each other thus contributing towards one’s happiness. Through family come together, there is a lot of sharing among family members which leads to happiness. Through sharing about past experiences, members of the family are able to reminisce about good memories they shared at earlier stages of life. This feeling provides happiness as they tend to reflect how their past had been hence forgetting current bad happenings hence emotional satisfaction and happiness (Lulu, 116).

Conventional implicit policy to my assumption has a strong relationship between happiness and family through equation with social well-being. The importance of additional family policy has an indication well-being emotionally in a state of happiness in connection to families at the level of psychology hence provide a better comprehensive understanding of a person’s well happiness and well-being. Family relations to me seem to

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Hello, I am looking for someone to write an essay on What is Conflict. It needs to be at least 750 words.

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Humans experience conflict everyday in their personal lives and in the organizational culture. Conflict can be interpreted in two dimensions: the theorist’s perspective of the conflict and the environment where the conflict takes place. The environment may include conflict between individuals or families or nations. The conflict can also be inter-psychic in which the conscious mind and the unconscious mind conflict with each other. Thus, conflict can occur in many contexts. How the mediators interpret conflict and its resolution paves the way to their selection of an appropriate approach towards reconciliation. Sarah Netter’s article, “Was Southwest passenger too fat to fly?” (2009) describes a conflict according to the above mentioned definitions of a conflict. The main character of the incident is an Illinois man, Emery Orto, who is 6-foot 350-pounds by size. He was returning to Midway to celebrate his wife’s birthday but the Southwest Airlines refused to let him fly from Las Vegas. He was not at all ready to purchase a second ticket despite his large size. Although Orto had been able to gain many people’s sympathies, the fact remains that he acted irrationally. Critical analysis of the incident tells that Orto was at mistake, not the Airlines. The personnel informed him that the customers unable to lower both armrests should book the additional seat at the booking time and that with only one seat, he was going to make himself uncomfortable as well as the co-passengers. The Southwest Airlines’ customer of size policy has it that the additional seat will be offered at a discounted rate and refunded afterwards if goes unoccupied, which is a very good offer which Orto should have availed. He had also been offered the opportunity to show to the Airlines that he could accommodate only one seat without upsetting his seatmates, but he refused. One cannot make out what was the reason he did not take the chance of boarding the plane and letting the personnel see that he was right. According to the Southwest Airlines (2009), putting forward the rule of an additional seat for large passengers became vital when the customers who felt terribly uncomfortable sitting next to an obese seatmate started raising objections. Moreover, the over-weight passengers disturb the plane’s weight and balance which is very dangerous. Since it is the responsibility of the Airlines to assure safety to all passengers, Orto had to be enquired. Hence, this conflict goes very well with the textbook’s definition of a conflict. 2. I would approach this conflict according to the Human Needs Theory, according to which basic human needs of a human being must be satisfied in order to resolve the conflict. Orto needs to be satisfied. however, he must also understand the policy of the airlines. The question that what factor decides which passenger is stout and which is skinny has a straightforward reply. The Airlines’ policy says that it is the size of the person that determines his obesity, not his weight nor the extension of the seat belt. If an obese person gets allowed to fly with only one seat, that would only happen if he is able to lower or extend the seatbelt. If he cannot lower it, this decides that he is obese. A good example can be of a pregnant woman. Despite her being over-weight, if she can lower the armrest, it is okay if she books one seat.

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