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Hello, I am looking for someone to write an essay on Monoclonal antibodies to epidermal growth factor receptor (EGFR) such as Cetuximab, are used to treat solid tumours but resistance to this treatment is a major clinical problem. It is essential to understand the mechanisms supporting the various forms of. It needs to be at least 2000 words.

ly against Epidermal Growth Factor Receptor (EGFR) in order to treat cancers such as metastatic colorectal cancer or lung cancer (Jean and Shah, 2008). In the cancer signalling pathway, EGFR, which belongs to the ErbB family of proteins, is activated upon binding with other receptors such as the peptide growth receptors (Normanno et al, 2006). Studies have shown that in patients with cancer the EGFR associated with peptide growth receptors is over expressed. Therefore, monoclonal antibodies which had been developed as inhibitors of EGFR along with conventional chemotherapy helped in prolongation of life in patients afflicted with cancer. However, complexity arose when certain patients with genetic alterations such as mutation in K-ras or PTEN instability showed resistance to the administration of the monoclonal antibodies which inhibited the success of the anti-cancer therapies and added to patient mortality. Several researchers focussed their studies on strategies to eliminate the resistance developed by the patients which called for an in-depth understanding of the resistance pathways. This paper, focuses particularly on two such studies- Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells by Kim et al (2010) and MEK1/2 Inhibitors AS703026 and AZD6244 May Be Potential Therapies for&nbsp.KRAS&nbsp.Mutated Colorectal Cancer That Is Resistant to EGFR Monoclonal Antibody Therapy by Yoon et al (2011).

Both of the papers have devised novel way to understand the development of resistance against treatment. In terms of theory both the papers looked into different aspects of the problem in terms of activation of EGFR. Yoon et al focused to understand the KRAS mutation induced resistance in colorectal cancer and come up with a plausible method to solve the problem. Colorectal cancer is a common form of cancer and has shown elevated expression of EGRF in the cells. However, the molecular therapy

 
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Hello, I am looking for someone to write an essay on MGMT442 U1 IP. It needs to be at least 500 words.

The candidate may quote how he had to let go of a team member after all his coaching failed.

In real life, a team leader has to switch between a person who can control and someone who participates in work if required. The role is won through experience and knowledge but maintained by instilling trust and promoting candor between amongst the team members (Collins, 2001). Another aspect important in this job is promoting a high performing culture. the team members should compete amongst themselves for rewards based on merit.

Here, the candidate must elaborate his knowledge and skills related to customer services. The means used to maintain and monitor service levels along with quality of customer services provided. It is also important that the incumbent must be aware of trends and technologies used in the service area by the firm’s competitors. Furthermore candidate must be aware of skill requirements both short and in long term (Krogerus & Tschappeler, 2008).

It is important that the interviewer must present the challenge that comes with this job. A demotivated, nervous and immature candidate would exhibit uncertainty, while the right incumbent would lay out a blue print of the plan right there and then. Furthermore it is important that the incumbent must elaborate what initial steps he would take in order to setup this department along with an approximate time period. This answer would indicate how the incumbents perform planning, organizing and controlling functions (Krogerus & Tschappeler,

 
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Hello, I am looking for someone to write an essay on Module 1 Small Scale Evaluative Study. It needs to be at least 2500 words.

Evaluation in schools is of interest to various stakeholders in the education sector i.e. the government, parents, teachers, media and the wider society (Bracey 2006).

Government inspectors have in many cases taken the roles of evaluation on schools’ performance in many countries although the new trend that is widely gaining prominence is that of schools doing self evaluation. Inclusion is one of the aspects of self evaluation that has been seen to have a wide range of positive outcomes if well implemented and it is for this reason that this paper shall seek to further on its impact on the evaluation process and how this can be facilitated by the SENCo (Swaffield and MacBeath 2005). It is a basic understanding that leadership should not be detached from the organs it is leading and it is for this reason that the process of inclusion is quite important in the cases of self evaluation for schools. All the stakeholders mentioned above need to work together and share ideas as evaluation is mostly the basis for school improvement and appraisal of standards of education.

Valuable outcomes have been seen to crop up in instances where the school management and the various stakeholders come together and give ideas or good as well as bad areas that need improvement and how best to do it. SENCo has the best chance and has their work well organised when such a scenario is in the offing. On basic terms the teaching staff for example should monitor leaning activities, manage performance of pupils, conduct department reviews and become actively involved in improvement and development activities of the school. Students with special needs have various disabilities that affect their learning and for this reason there are more aspects that need to be looked into more than the case would be in other schools. This is quite an interesting aspect to explore into and the findings of this paper shall come from various methods

 
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Hello, I am looking for someone to write an essay on Modern operating system. It needs to be at least 1000 words.

Microsoft’s Windows on the other hand is the opposite and it does not allow the users to bring about the changes in the source code or modify it. Apple Inc itself is a closed source operating system. The open source nature of Android makes it relatively flexible and more appealing towards the programmers. The added advantage of open source operating system is the presence of platforms and online societies supported by the given operating systems developer companies. The open source function provides the respective operating system an edge in the context of software support and software development. Android exhibits support for Linux based kernel, but this is not to be confused with the Linux operating system. The libraries of Android operating system vary considerably from those of the Linux operating system. The use of Dalvik Virtual machine by Android is a characteristic feature of Android which gives it an edge over the contemporary operating systems as well as the Linux operating system. The run time features include Dalvik as well as the libraries functions support. The Windows O.S kernel has seen considerable improvement in the recent times. It provides features such as System on Chip (SOC) along with the feature of User Mode Driver Framework (UMDF). In the recent times, the Microsoft O.S has come up with a dynamic outlook in the form of user platform and SOC supported kernel. Apple’ I.O.S kernel is a derivate of Unix Based system, however it does not copy or resemble the kernel of Linux or Android for each has its own designated and specific kernel.

 
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Hello, I am looking for someone to write an essay on Mobile Forensics: Mobile Phones Handsets, SATNA V, PDA, USB. It needs to be at least 2000 words.

Forensic study of mobile devices has existed, dating from the early 2000s. This was majorly introduced due to a proliferation of phones, more so the introduction of smartphones in the consumer market. Casey, Eoghan (2004). Digital Evidence and Computer Crime, Second Edition. Elsevier.

A lot of evidential and technical challenges have existed due particularly on the use of mobile phones which has been a threat to the security. For instance, the cell site analysis following from the use of a mobile phone usage has really not been an exact science. Though it is a possibility to determine roughly the geographical site from which a call was either made or received, it is still not possible to say with surety that a mobile phone call was done from a specific location, say a residential address. It is even of more challenge today that the original phone manufacturers are frequently changing the form factors of their mobile phone, data storage, the operating system file structures, peripherals, services, and not to forget pin connectors and even the cables. This is done for them to remain competitive in the market. As a result of this factor, forensic examiners are therefore forced to use a different forensic process as opposed to forensics. Another challenge is the continued growth of Storage capacity .in trial to cub and manage these challenges, several tools exist to extract evidence from mobile devices but it is true that no one tool or method can manage to acquire all the evidence from all devices. Due to this, It is recommended that forensic examiners.

 
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Hello, I am looking for someone to write an essay on Mitigation of Poverty Disaster: Towards Sustainable Economic Development. It needs to be at least 3000 words.

This research will begin with the statement that throughout human life, the inevitability of disasters cannot be disputed. The environmental changes that have arisen over time probably from mismanagement and irresponsible activities within the global surroundings have in most cases plunged the earth into a serious economic crisis. As a result, ‘perennial poverty’ has become a part and parcel of most communities especially those that are seasonally struck by these disasters. With the awareness of the perpetual incidences of these natural hazards, the world has responded in different fashions with different groups: local and global governmental and non-governmental organizations coming into place to help assist the victims as well as mitigate the occurrence of a similar disaster. ‘Hurricanes, volcanic activities, floods, famine among others are not any strange natural hazards that have had gross impacts on the lives of the victims. Poverty has become the long-term consequential impact Until today, ‘poverty disaster’ has grounded itself to challenge the economic stability of the world today especially in regions around the sub-Saharan region, the Middle East and other areas which are susceptible to various diseases, low embracement of modernity, ineffective leadership, lack of enlightenment among others. Poverty is a real disaster that has prompted the international bodies and financial aid institutions to rethink their strategies for approaching this menace. Poverty disaster can be mitigated using effective emergency planning to achieve a sustainable economic development. According to Brainard, Jones, and Purvis, poverty is a severe calamity that has a great embedment on the natural. Just the same way a flood would sweep away properties and claim casualties so do poverty. Poverty leaves the community affected non-functional and incapacitated such that they can hardly participate in any socio-economic activity that could build them. Poverty kills the same way any other hazard/disaster would and this attribute makes it be regarded as the threat. The fact that the poor are restricted from accessing basic facilities and services makes poverty be a chancy peril that is worse than other disasters. Collins describes poverty as a long-term nuisance that when it strikes it becomes extremely hard to alleviate. a feature that has made it be an elusive challenge that the world is still struggling to neutralize.

 
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Hello, I am looking for someone to write an essay on MIS- Hersey. It needs to be at least 500 words.

It appears that the company is sincere about living up to its mission statement – “Bringing sweet moments of Hershey happiness to the world every day”.1

Hershey made a decision to up date their hardware and software with a four-year plan. The company set goals which included standardizing the hardware and changing from mainframe to TCP/IP network. The company-reviewed information from Grocery Manufactures’ of America and this showed they were well behind on system updates, and expenditure on systems compared with similar companies in the industry.

The upgrading proved to be a bittersweet lesson2 for the company and cost them considerably in sales and credibility over nearly a 12-month period. The food and beverage industry in the country works on low profit margins and high volumes due to extensive competition. As a whole, investment in modernization of IT systems is low. But the Y2K threat required them to make major changes in their systems, and hence the Hershey management decided to go in for a major overhaul instead of tuning and adjusting the current system consisting of mainframes to client server environment. Many distributors and retailers felt that the delivery system of the company could be better tuned in order to reduce inventory costs. At that time, orders for peak time demand (Halloween) needed to be placed several months in advance for timely delivery. Unless Hershey complied, there was a chance that retailers and distributors may switch over to other manufacturers. Moreover, rising competition and low margins required higher turnover and a better equipped IT infrastructure was the only solution open. Customer loyalty is not high in the industry and they will switch over to other brands if Hershey’s products became unavailable. It will also enable Hershey to tackle high seasonal demand.

Due to peak demand during Halloween, Hershey

 
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Hello, I am looking for someone to write an essay on MVV-Mission, Vision, and Values. It needs to be at least 1000 words.

On its corporate website, Starbucks Company clearly states its mission, “to inspire and nurture the human spirit – one person, one cup and one neighborhood at a time” (‘Company Information,’ 2015). Concerning its values, company cares of creating specific culture, changing the world, being open to the external environment and offering its best products (‘Our Company’, 2015). Finally, vision of Starbucks to date is to “elevate our partners, customers, suppliers and neighbors to create positive change. To be innovators, leaders and contributors to an inclusive society and a healthy environment so that Starbucks and everyone we touch can endure and thrive” (‘Being a Responsible Company’, 2015).

Secondly, Caribou Coffee is younger, because its story starts from 1990. The corporate website does not write a lot about the contribution of people but talks more about “breathtaking panoramic view” as the real founder of the company (‘Out story’, 2015). In addition, Caribou has different term for its vision as “aspiration” to be “The Community Place I love” and replaces mission with commitment “to sharing an Extraordinary Experience that Feeds the Soul” (‘Our Culture’, 2015). Finally, it describes its core values by referring to the guests, community, team members, and own uniqueness (‘Our Culture’, 2015).

Thirdly, Canada-based popular Tim Hortons Company has the most long-term history among the analyzed coffee houses. Since 1964, Tim Horton and Ron Joyce became the co-owners and steadily turned Tim Hortons into franchise operating in both USA and Canada. Corporate website presents its mission statement as follows, “Our guiding mission is to deliver superior quality products and services for our guests and communities through leadership, innovation and partnerships” (‘Company facts’, 2015). Based on this, vision of the company is short, “to be the quality

 
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Hello, I am looking for someone to write an essay on Musical Theaters. It needs to be at least 500 words.

The first factor that made musical theater leap from “Oklahoma” to “Rent” is attributed to the uniqueness of the performances in theaters. (Everett & Laired, 2009). Theaters became revolutionized in that performances included singing, acting and dancing. The actions of. singing, acting and dancing instilled new life in the theaters, and eradicated the old fashion theaters, which only involved acting. In essence, the musical, “Oh what a beautiful morning” portrayed both aspects of signing and acting. The theme of the musical contained lyrics, which inspired a great number of people, and this made the musical very appealing (Everett & Laired, 2009). The second factor that made musical theaters leap from “Oklahoma” to “Rent” is related to the society. The musical “I will” by Jonathan Larson is performed by individuals from impoverished societies faced with negative issues such as poverty and AIDS. Through this, the theater became appealing since many individuals found relevance while in the theaters. Individuals in American societies and around the world, mostly the youths, found themselves on the negative side. Musicals such as “Oh what a beautiful morning” flourished as it touched a great number of individuals. The inspiring nature of the two musicals “Oh what a beautiful morning” and “I will” added with the drama and music definitely appeals (Everett & Laired, 2009).

 
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Hello, I am looking for someone to write an essay on Music and Soundscapes. It needs to be at least 250 words.

That simply illustrates the power of the musical score, or the music that is played in the background of a scene as action takes place (Goodykoontz & Jacobs, 2011).

The clip from the film “The Mask,” benefitted most from the power of sound effects. In general, rompy comedy clips do use a lot of exaggerated sound effects to enhance the humor in the scene and basically, to cue the laughter from the audience. The sound effects from the clip no doubt exaggerated the aspects of the scene but in a good way.

The last category of sound is dialogue. This is simply the conversation that goes on among, and sometimes within, the characters (Goodykoontz & Jacobs, 2011). In my opinion, this is also the part that turns off most men from “chick flicks,” with the clip from “When Harry Met Sally” to stress my point (Ladies, we get enough of that from you at home so imagine what two hours of that will do to

 
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