Hi, I need help with essay on Screening for novel peptides that block T-type calcium channels. Paper must be at least 1000 words. Please, no plagiarized work!

Effects of Ca2+ are most drastic at G1 phase of the cell cycle, where there is an increased expression of calmodulin and Ca2+-calmodulin-sensitive Cyclin D/CDK4 (Kahl and Means, 2003). However, cytoplasmic Ca2+ concentrations must be regulated such that it is high only when it needs to be, because a vital part of calmodulin-dependent kinase function is in its regulated stimulation. Persistent stimulation can cause modifications in calmodulin sensitiyity, such that a persistent high intracellular Ca2+ will eventually make calmodulin less sensitive to calcium ions (Kahl and Means, 2003). In addition, if neuronal CaM-kinases II are constantly activated, catecholamines cannot serve as neurotransmitters because there is no catecholamine concentration potential that indicates transmitted signal. If glycogen synthesis is constantly inhibited, chemical energy cannot be stored by the body in the form of glycogen (Alberts, et al., 2007 ).One of the major ways through which cytoplasmic Ca2+ concentrations are regulated is through T-type calcium channels.

T-type calcium channels are a group of low-voltage activated calcium channels. It has the characteristic six transmembrane alpha helices around a central pore. They open in response to even small membrane depolarization. Just like the enzymes it regulates, T-type calcium channels are also regulated. They are activated by cAMP-dependent protein kinase (PKA), which is directed to the phosphorylation site by an adapter called A-kinase anchor protein (AKAP). It is also regulated by intracellular Ca2+ concentration through calmodulin. Aside from those, protein kinase C can also activate T-type calcium channels. However, the activity of protein kinase C is counteracted by G-protein coupled receptors (Felix, 2005).

Because of the role of intracellular Ca2+ concentration to cell cycle, T-type calcium channels are associated with cell proliferation. Among normally differentiating cells which do not proliferate, expression of

 

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Hi, I need help with essay on Sammy, in A&P by John Updike Conflict between Sammy and his boss. Then Sammy wanted to be seen as a hero to these girls, then failed. Finally Sammy regrets his decision to quit his job. Paper must be at least 500 words. Please, no plagiarized work!

The author used the setting of the grocery store and first person narration to describe the changes in the thinking and pattern of Sammy’s acts and justification of his behavior and choices he made and consequences he faced as a result.

In the story, Sammy makes a leap from adolescent, knowing life a little more than it was in the grocery store, into a man that is able to head towards the rough patch of life. The grocery store setting helps to shape his imagination by the opportunities that it gives Sammy to expand his imagination. In the grocery store, there are a lot of items. This is an advantage for the author to use his imagination to compare the girls with the items available. Moreover, the store exhibits a place where a number of persons visit and Sammy exhibits prowess in understanding all of them, for Sammy the customers are all too easy to understand. The same goes for his boss and Stoksie, a 22- year old colleague and a friend. In the beginning he behaves as a sexist and describes one of his female complaining customer as a person without a brain in his statement “You never know for sure how girls’ minds work (do you really think it’s a mind in there or just a little buzz like a bee in a glass jar?”(Updlike)

The entrance of girls suggests to him the true mystery of other minds. Sammy wonders what they are thinking and describes them in detail using his imagination as a consequence of available free time at the store. For example he describes one of the girls face as a cherry and&nbsp.For instance, “She had sort of okay hair that the sun and salt had bleached, done up in a bun that was unraveling, and a kind of prim face” (Updlike,par.4).The author uses first person narration as tool to convey his ideas in a more helpful manner because it is more personal and helps convey the ideas and justifies Sammy’s behavior.

The story also tells us about the typical way men think about women. Sammy’s changing point of view about women

 

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Hi, I need help with essay on Sampling Techniques. Paper must be at least 250 words. Please, no plagiarized work!

To start with, probability sampling involves random selection and has four methods as follows. Simple random sampling where there is an equal chance of selection for every element. In systematic random sampling every nineth element is selected while stratified random sampling is one in which population is divided into segments (Trochim, 2004). Lastly cluster sample is where a particular subgroup is randomly chosen to represent the population under study.

In conclusion, non-probability random samples occur due to influence by certain factors. These factors are as follows: Convenience which is easy to find, purposive relating to the purpose intended, snowball sampling where the chosen subject suggests another, and finally quota which involves subgroups chosen to represent a quota of the population to be studied (Tille and Ardilly,187). Sampling advantages are time saving, economical, easy to adapt, reliable and indispensable. Limitations of sampling or inaccuracy in the results, expensive in terms of time and energy, unsuitable in that not applicable to other areas, and inherent defects in the

 

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Hi, I need help with essay on SAME SEX MARRIGE. Paper must be at least 750 words. Please, no plagiarized work!

f same-sex marriage, and whereas there are people who say they should be legalized and rely upon the equal rights for everyone, including gay persons, there are also those who find a lot of arguments against the legalization of homosexual marriages. Mostly those opposing the same-sex marriages claim that the gay people are normally not in the habit to be faithful to each other. However this can hardly serve as a reasonable and sound argument as not all hererosexuals are faithful and devoted husbands and wives.

Taking into account that there are multiple benefits (social and emotional) for people who get married, it becomes clear that it would be unfair to deprive gays and lesbians of their right to get married only on the ground of their sexual orientation. In fact, in many countries of the world and some states of America homosexual marriages have already been legalized. So it seems that soon the gay people all over the world will get the right to get married to their partners.

There are still, of course, some burning issues that are being argued about and discussed, such as adopting and bringing up children in homosexual families, however even these are being solved now in many world countries basing upon the presupposition of equal rights and equal opportunities for every human being.

How can marriage be defined? Marriage is the unity of two people who live together, and this unity should be acknowledged by the society. Such factors as having children, loving each other, and even official recognition (for in some places, it is still possible to marry without registration) are not necessary. It is normally taken for granted by the majority of people that marriages are concluded between two people of different sex. however in the course of history there have been plenty of examples of unities of people of the same gender, and these unities had all features of an “ordinary” marriage (Sparta, Ancient Greece, Rome, Ancient China and Japan).If we talk about

 

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Hi, I need help with essay on Sam Sheppard Questions and Answers. Paper must be at least 250 words. Please, no plagiarized work!

4. Is there any other viable alternative explanation from letters sent to the police? The letters specifically reflect diverse views of the members of the public given that this case is of public interest. Some letters are giving tips that can be helpful in carrying out the investigations of this case while others are expressing their sentiments as to whether Sam is guilty or not.

5. Is there additional information regarding injuries to Sam Sheppard at time of incident? It seems there is no sufficient information with regards to Sam Sheppard at the time of the incident. Focus is on the murder of Marilyn, his wife it is only stated that he was rushed to the hospital for treatment of his

 

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