Post 19477263

Respond  of your colleagues who were assigned to a different case than you. Explain how you might apply knowledge gained from your colleagues’ case studies to you own practice in clinical settings.

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                                  Sleep/Wake Disorders

The patient is an obese 70-year-old female with a chief complaint of “being sad.” Her husband passed away several years ago due to coronary artery disease (CAD). She lives at home alone and has a home health aide help her. Her son comes to visit her often. She was feeling well until her hearing began to diminish in both ears. Her mobility has declined, so she has not been able to get out as much. She is often lonely at home. She has daily crying spells, is often very tired, has good insight to her illness, and wants to get better. 

Three Questions to Ask the Patient and Why            

The case study mentioned that the patient is a candidate for cochlear implants, but it is a long way off. Thus, my first question to ask the patient is what is preventing her from getting cochlear implants?  

She began experiencing sadness when she began to lose her hearing and mobility. Therefore, regaining her hearing may help decrease the depression. If its financial reasons, maybe there are resources that can help her. Finding out the reason the patient isn’t getting the implants can help the provider and patient find solutions.             

The patient also mentioned that her sleep was “awful”, stating her legs “ache and jump”, she takes frequent naps during the day, and admits to snoring frequently. Thus, the second question I would ask is what are her sleeping habits like? 

Individuals who have good sleep habits sleep better. Getting better sleep can be obtained by being consistent by going to bed at the same time each night and waking up the same time each day (Centers for Disease Control and Prevention, [CDC], 2016).  Individuals can make sure the room is dark, quiet, and cool (CDC, 2016). Additionally, remove electronic devices, avoid large meals, caffeine, and alcohol can help with getting better sleep (CDC, 2016).              My third question would be what do you do when you are sad? Individuals who are depressed often have a negative view of the world and often think of themselves as worthless (This Way Up, n.d.). They often blame themselves when something bad happens and feel like they are unlucky (This Way Up, n.d.). Thus, helping individuals identify negative thinking and reframe the way they think about life can help improve depressive symptoms (This Way Up, n.d.). 

People to Speak to with Specific Questions to Ask 

The first person I would want to speak to is the patient’s son. The case study states the son visits her often so he should know the patient’s habits. First, I would ask him the same questions I asked the patient such as what is preventing the patient from getting cochlear implants, what are her sleep habits, and what does she do when she is sad? By asking the son the same questions, insight can be shown on how the son views things and how the patient views things. I would also him when he began to notice her depressive symptoms because that will help provide a timeline as to when it all began.             

The second person I would talk to is her home health aide because she is familiar with the patient. I would ask her what the patient’s home life is like such as how is she maintaining her house? Is she able to clean up after herself? How is she doing with activities of daily living? 

These questions can provide insight on the severity of the patient’s depressive symptoms. 

Physical Exams and Diagnostic Tests and How Results Would Be Used            

The first diagnostic test I would want to perform on the patient is the 9-item Patient Health Questionnaire (PHQ-9). The PHQ-9 is a screening tool for major depression (Na et al., 2018). The test is a reliable and valid measurement of depressive symptoms that also asks about the individual’s thoughts of death or self-injury within the last two weeks (Na et al., 2018). The results would be used to determine the severity of her depression. Another diagnostic test that can be performed on this patient is a polysomnography. A polysomnography is a sleep study that helps providers diagnose sleep apnea, periodic limb movement disorder, restless leg syndrome (RLS), insomnia, and nighttime behaviors (National Sleep Foundation, n.d.). The results would be used to can help determine the cause of her daytime sleepiness such as sleep apnea or RLS. I would also want to run a complete blood count (CBC) with differential on the patient. I would specifically want to obtain a red blood cell count (RBC) and white blood cell count (WBC). Thus, a CBC with differential would help determine if the patient is fatigued due to anemia or an underlying infection.

 Three Differential Diagnosis and Why

The three potential differential diagnoses include:Major Depressive DisorderPersistent Insomnia Disorder Obstructive Sleep Apnea Hypopnea The most likely differential diagnosis is major depressive disorder (MDD). The diagnostic criteria for MDD is five or more symptoms during the same 2-week period and a change from previous functioning (American Psychiatric Association, 2013).  The symptoms include: depressed mood most of the day, marked diminished interest or pleasure in all or almost all activities most of the day, significant weight loss or weight gain, insomnia or hypersomnia neatly every day, psychomotor agitation or retardation nearly every day, fatigue or loss of energy nearly every day, feelings of worthlessness or excessive or inappropriate guilt nearly every day, diminished ability to concentrate, and recurrent thoughts of death (American Psychiatric Association, 2013). The patient fits this diagnosis as evidence by depressed mood, diminished interest in activities she used to enjoy, fatigue, diminished ability to concentrate, and psychomotor retardation.

Two Pharmacological Agents and Dosing and Why 

One pharmacologic agent that can be tried is doxepin 3 mg at bedtime for insomnia. Doxepin works by boosting serotonin and norepinephrine by blocking the serotonin reuptake pump and norepinephrine reuptake pump (Stahl, 2017). At hypnotic doses, doxepin blocks histamine-1 receptors, which promotes sleep (Stahl, 2017). Doxepin is a substrate for CYP450 2D6 and has a half-life of 8-24 hours (Stahl, 2017). In the elderly, the recommended dose for insomnia is 3 mg per day (Stahl, 2017).             Another pharmacologic agent that I would like to start the patient on is bupropion (extended release) XL 150 mg daily in the morning. Bupropion is used to treat MDD and works by boosting norepinephrine and dopamine by blocking the norepinephrine reuptake pump and dopamine reuptake pump (Stahl, 2017). Bupropion inhibits CYP450 2D6, has a parent half-life of 10-14 hours, and a metabolite half-life of 20-27 hours (Stahl, 2017). Thus, since bupropion blocks the dopamine reuptake pump and norepinephrine reuptake pump, this medication is beneficial in improving symptoms of loss of happiness, joy, interest, pleasure, energy, enthusiasm, alertness, and self-confidence (Stahl, 2013). Thus, because of bupropion’s mechanism of action and the patient’s symptoms, I would want this patient to try this medication. 

Lessons Learned  

Lessons learned during this case study is that geriatric depression can be difficult to treat. They often have multiple comorbidities with the possibility of more pronounced side-effects (Stahl, 2008). Additionally, medications can have contraindications that do not previously exist prior to the patient being put on medication. Thus, providers must be aware of new and old warnings on medications in the event there are changes made to medications. I will apply this information when I am in practice by paying close attention to dosages, side effects, and potential contraindications when providing medication to the geriatric population. 

                                                  References

American Psychiatric Association. (2013). Diagnostic and statistical manual od mental disorders (5th ed.). Washington, DC: Author. Centers for Disease Control and Prevention. (2016). Tips for better sleep. Retrieved from https://www.cdc.gov/sleep/about_sleep/sleep_hygiene.htmlNa, P. J., Yaramala, S. R., Kim, J. A., Kim, H., Goes, F. S., Zandi, P. P.,…Bobo, W. V. (2018). The PHQ-9 item 9 based screening for suicide risk: a validation study of the Patient Health Questionnaire (PHQ-9)-9 item 9 with the Columbia Suicide Severity Rating Scale (C-SSRS). Journal of Affective Disorders, 232, 34-40. doi: https://doi.org/10.1016/j.jad.2018.02.045National Sleep Foundation. (n.d.). Sleep apnea. Retrieved from https://www.sleepfoundation.org/sleep-apneaThis Way Up. (n.d.). How do you feel? Retrieved from https://thiswayup.org.au/how-do-you-feel/sad/Stahl, S. M. (2008). Essential psychopharmacology online. Retrieved from https://stahlonline-cambridge-org.ezp.waldenulibrary.org/viewPdf?page=csEP_16.pdf&vol=2Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical    applications (4th ed.). New York, NY: Cambridge University Press. Stahl, S. (2017). Stahl’s essential psychopharmacology: Prescriber’s guide (6th ed.). San Diego,  CA: Cambridge University Press. 

 
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Post Brandy Ni 19180349

 Respond to the post bellow offering additional/alternative ideas regarding opportunities and risks related to the observations shared. 

 

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     I am currently a home telehealth nurse for a  large VA hospital. I worked bedside for 17 years prior my current  position. Unlike the inpatient setting, the technology and advancement  made for the telehealth programs within the VA are impressive and  evolving rapidly.

Technology Trends and Risk

     An obvious trend within the VA system is the  expansion of technology within the telehealth program. A large  percentage of the veterans live in rural areas.  At the time, home  telehealth technology is limited to monitoring patients with chronic  diseases through platforms via PC, a device to manually enter readings  daily, mobile apps, and manually entering readings through a phone  number.  The VA is now trending toward video assisted monitoring with  home telehealth.   There are physician’s offices and community-based  clinics are already using this technology. The primary challenge with  this technology is the accessibility of reliable signal strength to  patients in rural areas.  An additional struggle is difficulty with  these veterans working with this technology. 

Data Safety

     The VA medical system has an adequate privacy and  security protection as it relates to data safety and information sent  through telemedicine modalities.   The VA has a dedicated department  that strictly monitors all data activity. Despite the security in place  there are risk, specifically with telehealth transmission of personal  health information. These risks include accidental transmission of  household information and activities including personal interactions  with family members or indicators when the patient may not be home (Hall  & McGraw, 2014).

Patient Care

     Patient care benefits of telemedicine are  endless. These benefits include less travel time, real time monitoring  of medication changes, monitors patients with chronic condition like  COPD and CHF closely to prevent or address acute episode (McGonigle  & Mastrian, 2018).  This cuts down on office visits and travel time.  More importantly, healthcare management is achieved sooner improving  overall patient outcomes.  Patient’s rely heavily on monitoring from  home creating a potential risk.  Often these patients with chronic care  management are not compliant with transmitting information or  information is sent inconsistently making it difficult to assist with  achieving overall goals.

Legislation

Telehealth  technology allows providers to treat remotely defined by state-by-state  licensure (Milstead & Short, 2019).  The benefit of state  regulation is the ability to closely monitor practice and outcomes on a  state level. The federal government is considering nationalizing the  regulations for telehealth. This presents a dilemma as physicians  practicing telehealth will require multi state licenses.  

     I believe the most promising healthcare trends  impacting healthcare technology and nursing practice is the advancement  of telemedicine.  The ability to remotely monitor patients and maintain a  consistent record provide information for time sensitive diagnosis and  treatment.  The impact this has on nursing is profound. Nurses will be  responsible not only for monitoring but for teaching these patients how  to manage these problems themselves. The nurse’s consistent  communication allows for education not only with medication but with  diet, exercise, weight loss and overall prevention.  Telehealth is a  promising tool to the new culture of preventative healthcare. While  patients are in the program, they can interact and learn about their  disease process and exacerbation prevention. Telehealth is a win win.

                                                                                                    References

Hall, J. L., & McGraw, D. (2014). For  Telehealth to Succeed, Privacy and Security risks must be Identified and  Addressed []. Health Affairs, 33(2).                        https://doi.org/https://doi.org/10.1377/hlthaff.2013.0997

McGonigle, D., & Mastrian, K. G. (2018). Nursing Informatics and the Foundation of Knowledge (4 ed.). Burlington, MA: Jones & Bartlett Learning.

Milstead, J. A., & Short, N. M. (2019). Health Policy & Politics A Nurse’s Guide. Burlington, MA: Jones & Bartlett Learning Books.

 
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Post Brandy Ni 19165339

Respond  by offering one or more additional mitigation strategies or further insight into your colleagues’ assessment of big data opportunities and risks.

                                                                  

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      Big data provides knowledge, insight, ideas and the potential to expand opportunities within an organization (McGonigle & Mastrian, 2018, p. 478).  Considerable amounts of data have been collected through the EMR over the past decade creating a challenge for nurse scientist to find nuggets of information in tsunami of data (Gephart, Davis, & Shea, 2017). The amount if big data can be difficult for those required to examine and retrieve information. Despite the overwhelming amounts of big data, it does come with benefits, challenges and risk associated with its use.

     A benefit to using big data is the ability to communicate with a large group of patients at one time. For instance, a physician can send a message out to a large group of patients in a short period of time with the use of big data (Laurete Education, 2018).  A physician’s office can remind large group of patients of appointment reminders, lab appointments or alert them to call the md office with abnormal lab results.  This cost effective and convenient as it allows consistent measures to monitor the practice.

     A potential challenge of using big data is the fine line of deciding who owns and who can use the data (Shanthagiri, 2014). For example, the data sources include the patient’s private health information which could now be potentially shared with labs, pharmacies, social media in addition to their physician (Shanthagiri, 2014).  The enforcement of privacy of PHI and HIPPA is strict. The potential for error with big data is a high risk.

     Working with the VA medical center, I observe strict monitoring and firewalls ensuring safety of patient’s PHI. The vulnerability of exposure of personal health information to social media or social networks is a constant threat.  The EMR not only stores health data but also houses the patient’s personal information such as social security numbers, addresses, and birthdays. A strategy to combat this potential problem is a strong malware and security system monitored 24 hours a day 7 days a week. The VA medical center monitors all information going in and going out of the EMR with it’s own security department specific for data protection.  Each user is tagged to this information and can be traced.  The VA will immediately terminate privileges should a user of the EMR violate any firewall in the system. They monitor everything as they should.

      As a bedside nurse I am aware of my contribution to this data however, I am not exposed to the cumbersome job of disentangling this information or protecting it. I know the potential benefit of collecting this information is to provide information as it relates to quantifying and qualifying illness, providing evidence for practice.  That being said, big data will continue to grow as we knowledge workers continue to contribute and technology advances.

References

Gephart, S., Davis, M., & Shea, K. (2017, December 13, 2017). Perspectives on Policy and the Value of Nursing Science in a Big Data Era. SAGE Journals.         https://doi.org/https://doi-org.ezp.waldenulibrary.org/10.1177/0894318417741122

Laurete Education. (2018).  Health Informatics and Population Health: Analyzing Data for Clinical Success [Video file]. Retrieved from                                       https://class.waldenu.edu/bbcswebdav/institution/USW1/201950_27/MS_NURS/NURS_5051_WC/USW1_NURS_5051_module03.html?course_uid=USW1.1425.201950&service_url=https://class.waldenu.edu/webapps/bbgs-deep-links-BBLEARN/app/wslinks&b2Uri=https%3A%2F%2Fclass.waldenu.edu%2Fwebapps%2Fbbgs-deep-links-BBLEARN#resources

McGonigle, D., & Mastrian, K. G. (2018). Nursing Informatics and the Foundation of Knowledge (4 ed.). Burlington, MA: Jones & Bartlett Learning.

Shanthagiri, V. (2014). Big Data in Health Informatics [Video file]. Retrieved from https://www.youtube.com/watch?v=4W6zGmH_pOw

 
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Post Cristopher

Respond  on two different days by making recommendations for how they might strengthen the leadership behaviors profiled in their StrengthsFinder assessment, or by commenting on lessons to be learned from the results that can be applied to personal leadership philosophies and behaviors.

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Through this week’s resources, we have learned what a leader is. Last week we focused on theories and examples of leaders we have witnessed firsthand. This week we are focusing on ourselves individually. After taking Gallup’s Strengths Finder assessment, I was given five signature themes.  

My Signature Themes 

Before going over my specific themes, I must first explain the domain’s they rest under. My themes were either under the executing or the relationship builder domains (Strengths Finder, 2018). The executing domain is about knowing, “how to make things happen” (Strengths Finder, 2018, para. 3). The relationship domain encompasses themes that are involved with providing, “the essential glue to hold a team together” (2018, para. 1). The themes that I had under the executing domain were restorative and consistency. These themes are defined as being able to deal with problems and treating people with equality, respectively. The themes I had under the relationship domain were developer, empathy, and harmony. Developers, “cultivate the potential in others” (Strengths Finder 2018, para. 2). Empathy is focused on sensing other’s feelings and harmony is focused on looking for consensus (2018).  

Room for growth 

After reviewing the Strengths Finder assessment, now I will point out a few areas for improvement. Starting with values, I have chosen courage and service as two values I would like to improve (MasonLeads, 2019).  None of the themes I had were under the domain of influencing (StrengthsFinder, 2018). I believe with more courage this would change. Two potential strengths I would improve would be activator and analytical. People who are adept at activating, “can make things happen by turning thoughts into action” (2018, para. 1). It is also under the influence domain. Another domain I didn’t exemplify with strategic thinking. The analytical theme is under this domain and people who demonstrate this, “search for reasons and causes” (StrengthsFinder, 2018, para. 1). Two characteristics I would like to improve are the ability to self-manage and to make difficult decisions (Yscouts.com, 2019). Nowhere in my results was there any mention of self-management skills or the ability to make tough decisions. These two characteristics are crucial to be a transformational leader.  

The Strengths Finder assessment was an eye-opening tool. I learned my strengths, but, more importantly, I learned my weaknesses. Being able to improve upon my weaknesses will bring me one step closer to a transformational leader.  

References 

MasonLeads. (2019). Core Leadership Values. Retrieved from https://masonleads.gmu.edu/about-us/core-leadership-values/ 

Strengths Finder: Gallup. (2018). Retrieved from https://walden.gallup.com 

Strengths Finder: Gallup. (2018). Retrieved from https://walden.gallup.com/application/strengthsquest#domain 

Yscouts. (2019). 10 Transformational Leadership Characteristics. Retrieved from https://yscouts.com/10-transformational-leadership-characteristics/ 

 

 
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Post Chrismene

Respond  to at least two of your colleagues who were assigned a different patient than you. Critique your colleague’s targeted questions, and explain how the patient might interpret these questions. Explain whether any of the questions would apply to your patient, and why.

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                                         CASE STUDY 2 

AG is a 54-year-old Caucasian male who was referred to the clinic to establish care after a recent hospitalization after having a seizure related to alcohol withdrawal. He has hypertension and a history of alcohol and cocaine abuse. He is homeless and is currently living at a local homeless shelter. He reports that he is out of his amlodipine 10 mg which he takes for hypertension. He reports he is abstaining from alcohol and cocaine but needs to smoke cigarettes to calm down since he is not drinking anymore.

The Communication Techniques

A nurse practitioner chooses to use the RESPECT Modell to communicate with the patient to stay productive and patient-centered in all her communication with the patient. RESPECTS stand for (Rapport, Empathy, Support, Partnership, Explanation, Cultural Competence, and Trust) (Ball, Dains, Flynn, Solomon, & Stewart, 2019). The nurse practitioner establishes rapport by seeking the patient’s point of view to avoid being judgmental. She asked the question of how the patient wanted to be addressed. The nurse practitioner shows empathy by asking the patient how he becomes homeless to understand how she can help him get his life back in order. The nurse practitioner supports the patient by asking him about his financial situation to direct him to the proper agency. The patient is at risk for cardiac diseases, lung cancer, and stroke, so the nurse practitioner partnered with the patient to help him stop smoking (Ball et al., 2019).The nurse practitioner needs to explain to the patient to know what cigarette smoking does to the body. Nicotine is a sympathomimetic medicine that releases catecholamines, increases heart rate and cardiac contractility, constricts cutaneous, and coronary blood vessels, and rapidly increases blood pressure (Benowitz, 2009). It is crucial to present the patient with evidence-based practice to address health risks across cultures, and it is essential to assure the patient that what he said will be kept confidential to establish trust (Ball et al., 2019).

The Risk Assessment Instrument

The CAGE questionnaire is a precise tool that has been used for many years to screen patients for addictive behaviors. The GAGE questions have been modified to apply to smoke behavior.  The CAGE questions are as following: 1) Have you ever felt the necessity to cut down or control your smoking, but had trouble doing so? 2) Do you ever get angry or annoyed with people who criticize your smoking or demanding you quit smoking? 3) Do you feel guilty regarding your smoking or about something you did while smoking? And 4) Do you ever smoke within half an hour of waking up (Eye-opened)? The patient is screen positive to two yes responses. The CAGE instrument is used because it is nonthreatening. A study showed that the CAGE questionnaire was used in a medical outpatient embedded in a self-administered questionnaire regarding health habits. Most of the patients did not know that they were filling out an assessment for addictions. The patient must be willing to stop smoking for treatment to be effective (American Family Physician, 2000).

                                      Targeted Questions

1)     How do you want to be addressed?

2)     How are you feeling?

3)     How may we help you?

4)     How do you become homeless and tell us about your financial situation?

5)     Do you need help getting your prescription refill?

6)     When was the last time you drink alcohol or use cocaine?

7)     When was the last time you check your blood pressure and take your amlodipine medication?

8)     When was the last time you had a seizure episode?

9)     When do you start smoking and how many packs do you smoke a day?

10) How can we help you to stop smoking?   

           

                                                References

Ball, J. W., Dains, J. E., Flynn, J. A., Solomon, B. S., & Stewart, R. W. (2019). Seidel’s guide to physical examination: An interprofessional approach (9th ed.). St. Louis, MO: Elsevier Mosby.Benowitz, N. L. (2009). Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annual review of pharmacology and toxicology49, 57–71. doi:10.1146/annurev.pharmtox.48.113006.094742American Family Physician. (2000). Assessing Nicotine Dependence. Retrieved from https://www.aafp.org/afp/2000/0801/p579.html

 
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Post Casey

 Respond by offering additional thoughts regarding the  examples shared, Systems Development Life Cycle SDLC-related issues, and  ideas on how the inclusion of nurses might have impacted the example  described by your colleagues.
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Consequences of a Healthcare Organization not Involving Nurses

Nurses are the backbone of healthcare and when they are not involved in the design and decision-making processes of the Systems Development Life Cycle the results can be catastrophic. According to the authors Powell-Cope & Nelson (2008), nurses are the frontline and chief users of electronic health record (EHR) systems, it only makes sense they’d have a major say in EHR design and upgrades. Unfortunately, however, in many facilities, EHR design is left primarily to IT and only minor input is taken into consideration from the nursing staff. When subject matter experts, such as nurses, don’t have autonomy and responsibility within the design process, implementing and utilizing an EHR can take longer because providers are distanced from the outcomes (Powell-Cope & Nelson, 2008). 

Inclusion of Nurses in EHR Design

When nurses are included in technology design, it enables and enhances safety (Hamer & Cipriano, 2013). A study was done in 2009 on early nursing involvement during the implementation of a Bar Code Medication Administration (BCMA) system. The authors of this study describe how nurses participated in the early design, planning, implementation, and evaluation phases of the BCMA. The study found that the benefits of early nursing involvement in each phase of BCMA technology greatly outweigh the problems that can arise from early nursing involvement (Weckman & Jansen, 2009). This study found that in order to find success when implementing new technologies, it is essential that nurses be involved throughout all phases of the process. Comments and feedback from nurses provide the necessary clues that are needed to resolve underlying systemic issues and can offer possible resolutions.   

My Personal Input

My current healthcare facility is changing its EHR system to Epic. They have selected a specific team of nurses and nurse informaticists that are currently part of their healthcare team, to design and adapt the Epic program to meet the institution’s requirements. My facility has named their adaptation of the Epic EHR to Elle. The entire healthcare team has been invited to monthly townhouse meetings which involve disclosing the most recent updates made to Elle and team members are also encouraged to provide input on any modifications they would like to add to Elle. As critical nurses, we are excited that we will finally have a charting system that downloads our vital signs electronically. Before Elle, we had to write our vital signs every 15 minutes on each of our two patients. It might not seem like a big deal, but writing vital signs for two patients can take up a considerable amount of time, especially when a patient is unstable and on multiple drips. If nurses were not involved in the EHR design, downloading vital signs might be something that was overlooked again. 

References

Hamer, S., & Cipriano, P. (2013). Involving nurses in developing new technology. Nursing Times,     109(47). Powell-Cope, G., Nelson, A. L., & Patterson, E. S. (2008). Patient Care Technology and Safety.     Retrieved April 22, 2019, from https://www.ncbi.nlm.nih.gov/books/NBK2686/ Weckman, H. N., & Jansen, S. K. (2009). The Critical Nature of Early Nursing Involvement for     Introducing New Technologies. The Online Journal of Nursing Issues, 14(2).

 
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Post Casey 19490227

 Respond to at least two of your  colleagues who were assigned to a different case than you. Explain how  you might apply knowledge gained from your colleagues’ case studies to  you own practice in clinical settings. 

NOTE: Positive Comment

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      Case #13 the 8-year-old girl who was naughty  

         

This  case study will examine an 8-year-old girl who initially presents to  the pediatrician’s office with complaints of a fever and sore throat.  After further examination, the client is diagnosed with attention  deficit hyperactivity disorder (ADHD) and oppositional defiant disorder  (ODD). According to Ghosh, Ray, & Basu (2017), characteristics of  ODD include persistent anger or irritable mood, argumentativeness,  defiance, and vindictiveness for at least 6 months. ADHD is  characterized by a pattern of inattention, hyperactivity, and  impulsivity that interferes with daily functioning or development  (American Psychiatric Association, 2013). 

3 Additional Assessment Questions for the Client:

1.  I would ask the client and her mother how often her daughter displays  symptoms that are congruent with ODD and? According to the authors  Ghosh, Ray, & Basu (2017), the occurrence of ODD symptoms must be  disproportionate to the child’s developmental stage and age. 

2. I  would ask the client if she had trouble learning in class when she was  younger. The onset of ADHD symptoms usually occurs before a child  reaches age 12, and in some children, these symptoms are noticeable at  age 3 (Sibley, Rohde, & Swanson, 2017). 

3. A  final question that I would ask the client is if she interrupts her  classmates when they are speaking. Children suffering from ADHD feel the  need to be constantly active and struggle with controlling impulsive  behaviors (American Psychiatric Association, 2013).  

Feedback From the Client’s Loved Ones

The  first person in this client’s life that I would like to further  interview is the client’s mother. According to Stahl (2019), the  client’s mother is 26 years old and is a single parent of two children,  ages 8 and 6. I would want to ask the client’s mother more about her  daughter’s academic performance in earlier grades. Identifying the  precise onset of the client’s ADHD symptoms will assist the provider in  creating the most appropriate treatment for the client (Stahl, 2014). I  would also like to interview the client’s teacher in order to gain  another perspective on the client’s behavior in the classroom. The  client’s teacher did use an ADHD rating scale, but scales of that nature  are very broad and do not elaborate on the child’s specific classroom  behaviors. A third person that I would interview is the client’s  6-year-old sister. According to Stahl (2019), the client began  displaying signs of anger and resentfulness when her sister was born. I  would ask the client’s sister if she felt safe at home and if she and  her sister fought often, in order to determine if the home environment  is safe for both children. 

Physical Exams and Diagnostic Tests

The  physical assessment of the client is essential for developing an  appropriate diagnosis and treatment plan. Visual assessment of the  client’s behaviors during the physical assessment will be extremely  useful to the provider. The provider would also want to obtain and  review the client’s report cards along with any behavior reports, and  attendance records from the client’s school (Adesman, 2011). The  healthcare provider should also review the client’s pediatric health  records to see if her symptoms are congruent with a learning disability,  auditory processing disorder, signs of language delay, spacial  orientation confusion, and complete a more thorough family history  involving learning disabilities (Adesman, 2011). A complete blood count  should be down to rule out physical illness as a causetive factor for  the client’s ODD symptoms. The client is currently suffering from a  fever and sore throat, which could be an indicator of PANDAS (pediatric  autoimmune neuropsychiatric disorder associated with streptococcal  infections). Since  the client does have a current sore throat, a rapid strep test should  be ordered. If the client does test positive for strep, it could explain  the client’s symptomologies impulsivity, temper tantrums, and aggressiveness.  

Differential Diagnoses

Autism Spectrum Disorder: there  are deficits in social-emotional reciprocity, ranging from an abnormal  social approach and failure to communicate in a standard back-and-forth  conversation (American Psychiatric Association, 2013). There is also a  reduced sharing of interests, emotions, or affect, along with a failure  of the patient to initiate or respond during social interactions (American Psychiatric Association, 2013). The client’s history does not show any indication of impaired communication. 

Conduct Disorder:  characterized by behavior that violates either the rights of others or  major societal norms, the symptoms must be present for at least 3 months  with one symptom having been present in the past 6 months. The symptoms  of conduct disorder must cause significant impairment in social,  academic or occupational functioning (American Psychiatric Association,  2013). Per the client’s medical record, her symptoms fit the time frame  for conduct disorder, however, her behavior is not this severe in  nature. 

ADHD with Co-occurring ODD: The authors Ghosh, Ray, & Basu (2017), describe the characteristics  of ODD as persistent anger or irritable mood, argumentativeness,  defiance, and vindictiveness for at least 6 months. ADHD is  characterized by a pattern of inattention, hyperactivity,  and impulsivity that interferes with daily functioning or development  (American Psychiatric Association, 2013). The client’s behavior is  congruent with ADHD with co-occurring ODD.

Pharmacological Agents for ADHD/ODD Therapy: 

Risperdal  is the first pharmacological agent that I would choose for this client.  This medication is not listed on the suggested medication list of the  case study, however, the medication list does list “other” as a possible  choice. According to Stahl (2014), Risperidone  is also used to treat behavior problems such as aggression,  self-injury, and sudden mood changes in teenagers and children 5 to 16  years of age. Risperidone  is in a class of medications called atypical antipsychotics. It works  by changing the activity of certain natural substances in the brain. The  second medication that was chosen for this client is Vyvanse.  Vyvanse increases norepinephrine and dopamine actions by blocking their  reuptake and creating an environment that allows their release (Stahl,  2013). Vyvanse also causes an enhancement of dopamine and  norepinephrine in specific areas of the brain that may improve  attention, concentration, executive dysfunction, and wakefulness (Stahl,  2013). According to Stahl (2014), it is thought that the increased  dopamine action caused by Vyvanse, may help with hyperactivity. I would  initially start this client on Vyvanse due to its efficacy in treating  symptoms of ADHD. If the child’s academic performance and classroom  behavior improve, perhaps ODD symptoms will improve. 

   

CheckPoints: 

According  to Stahl (2019), the closest child psychotherapist is an hour away,  therefore the client did not receive therapy. I would refer the client  and her mother to case management in order to connect the client with  resources that are closer to her home. I would also ask the client’s  school what type of resources are available in terms of psychotherapy.

Lessons Learned: 

Through  this case study I have learned that co-occurring childhood disorders  can be difficult to treat. Pediatric clients can respond differently to  medication dosages than adults, so careful dose titration is essential.  Pediatric clients also rely on their parents or caregivers to provide  them with their prescribed medications and transportation to medical  appointments. It is essential that the healthcare provider conveys how  important treatment regime compliance is to both the client and their  caregiver.

Adesman, A. R. (2011). The Diagnosis and Management of Attention-Deficit/Hyperactivity Disorder in     

          Pediatric Patients. Primary care companion to the Journal of clinical psychiatry, 3(2), 66-77.     

          https://doi.org/10.4088/pcc.v03n0204

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders

(5th ed.). Washington, DC: Author.

Ghosh, A., Ray, A., & Basu, A. (2017). Oppositional defiant disorder: current insight. Psychology     

research and behavior management, 10, 353-367. https://doi.org/10.2147/PRBM.S120582

Sibley, M. H., Rohde, L. A., & Swanson, J. M. (2017). Late-Onset ADHD Reconsidered with     

           Comprehensive Repeated Assessments between Ages 10 and 25. American journal of psychiatry,     

175(2), 140-149. https://doi.org/10.1176/appi.ajp.2017.17030298

Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (fourth ed.). New York, NY: Cambridge University Press.

Stahl, S. M. (2014). The prescriber’s guide (5th ed.). New York, NY: Cambridge University Press.

Stahl Online. (2019). Volume 1 case #5: The sleepy woman with anxiety. (PDF file). 

Retrievedfrom http://stahlonline.cambridge.org.ezp.waldenulibrary.org/viewPdf?p

age=csEP_05.pdf                

 
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Post Casey 19465791

Respond to at least two of your colleagues who were assigned to a different case than you.  Explain how you might apply knowledge gained from your colleagues’ case studies to you own practice in clinical settings.

    If your colleagues’ posts influenced your understanding of these concepts, be sure to share how and why. Include additional insights you gained.

    If you think your colleagues might have misunderstood these concepts, offer your alternative perspective and be sure to provide an explanation for them. Include resources to support your perspective.

       

                                                                   Case #7 

The Case: The case of physician do not heal thyself

The Question: Does the patient have a complex mood disorder, a personality disorder or both?

The Dilemma: How do you treat a complex and long-term unstable disorder of mood in a difficult patient?

*List three questions you might ask the patient if he or she were in your office: 

1. Has there ever been a period of time when you were not your usual self and thoughts raced through your head or you couldn’t slow your mind down (Hirschfeld, 2002)? 

Rationale: This question specifically inquires about whether the client feels they have been their usual self and specifically references their energy levels (Hirschfeld, 2002). These symptoms are important to identify and rule out if a manic episode related to a mood disorder (such as Bipolar I) is occurring. By narrowing down correct symptomologies, the correct and appropriate psychiatric diagnosis can be made, along with the appropriate treatment. 

2. Has your mood or behaviors caused major problems in your life like being unable to work; having a family, money or legal troubles; getting into arguments (Hirschfeld, 2002)?

Rationale: This question specifically focuses on how much of a problem the symptoms have been in a client’s everyday life. Mood disorders such as Bipolar I and Bipolar II can significantly impact a client’s life. Patients suffering from a mood disorder, such as Bipolar I, are at a significantly higher risk for suicide, harm to self, or harm to others (Hirschfeld, 2002). 

3. How frequently would you estimate that you have experienced racing thoughts or elevated energy in relationship to your mood or fights and have any of these issues occurred during the same period of time (Hirschfeld, 2002)? 

Rationale: This particular question addresses if the symptoms that are being experienced, occurred during the same time period, which would be indicative of the diagnosis of Bipolar I mood disorder. This question is important when assessing a client for a mood disorder in those patients who are misdiagnosed may experience rapid cycling or mania (Hirschfeld, 2002). 

*Identify people in the patient’s life you would need to speak to or get feedback from to further assess the patient’s situation. Include specific questions you might ask these people and why.

According to Stahl (2013), it is essential for healthcare providers to obtain information from not only the client but also from outside sources. Outside sources for a client may include their spouse, parents, or siblings. Information obtained from outside sources may be significantly different than what the client describes and can assist in accurately diagnosing the client (Stahl,2013). Clients that are accurately diagnosed, can then be appropriately treated with pharmacological agents.  

-Were there any significant triggering factors related to the client’s first major depression episode at age 23? 

These questions can assist in distinguishing between Bipolar Mood Disorders and Borderline Personality Disorder. Bipolar Mood Disorders typically manifest in the early to mid-’20s ( It must be determined if the depression was an initial onset of a hypomanic episode or if it was due to an existing personality disorder. 

-What other moods did the client exhibit when they were not in a depressive episode? How long did these moods last?

According to Stahl (2013), individuals often downplay their manic symptomologies and their duration. These episodes and their duration are essential in order to accurately diagnosing a client. 

-Does the client have any significant psychiatric history, such as Bipolar I, Bipolar II, or other mood disorders?

According to Stahl (2013), first-degree relatives who also have bipolar disorder can indicate the likelihood that the client also suffers from a bipolar disorder. If the client does have a significant family history of bipolar disorder, any effective treatments, the severity of the condition, and any hospitalizations that occurred should be documented in the client record.  

Explain what physical exams and diagnostic tests would be appropriate for the patient and how the results would be used.

Certain diagnostic tests such as a Complete Metabolic Panel (CMP), Liver Function Tests (LFT’s), Hemoglobin A1c, and a urine specific gravity can be ordered to evaluate the functionality of the client’s kidneys, liver, and the presence/risk of diabetes mellitus. A mood stabilizer such as Lithium may be used to manage the client’s severe fluctuation in moods. Lithium, however, can be severely nephrotoxic. Kidney function tests should be drawn prior to initiating therapy and throughout the course of therapy to assess for kidney dysfunction (Tolliver & Anton, 2015). A urine specific gravity can also indicate the functionality of the kidneys. Antipsychotic medications may be used to treat long-term unstable mood disorders. Antipsychotic medications, both first and second generations, can cause metabolic syndrome. The development of metabolic syndrome can be monitored by obtaining a CMP, LFTs, & Hemoglobin A1C prior to starting medication therapy and then throughout the medication therapy course. According to Stahl (2013), clients taking antipsychotic medications should have lab diagnostic studies done every 3-6 months. A urine drug screen (UDS) should also be done to rule out the illicit substances as the causation of the mood disorder. 

It is essential to assess all clients if they have any suicidal ideations. The Columbia-suicide severity rating scale can be used to assess the severity of suicide risk. COLUMBIA-SUICIDE SEVERITY RATING SCALE (C-SSRS): This screening tool is used to detect suicidal ideations and their severity. It is scored from 0-5. A score greater than 0 may indicate a need for mental health intervention. A score of 4-5 indicates active suicidal ideation with some intent to act (“Columbia-Suicide Severity,” 2019). 

This client should have a full head-to-toe physical assessment completed including a mental status exam, and vital signs. These initial findings can be used as a baseline for the patient and any future assessment changes can be compared to the initial findings (Tolliver & Anton, 2015).

**List three differential diagnoses for the patient. Identify the one that you think is most likely and explain why.

1. Recurrent major depression with an anxious/dysphoric temperament Most likely diagnosis

According to the DSM V (2013), the client’s symptoms most likely indicate a mood disorder. Due to the limited amount of time with the patient and limited past mania history, a Bipolar mood disorder could be ruled out. The client’s main symptoms present as depressive in nature, with one suicide attempt 40 years ago (Stahl Online, 2018). Recurrent major depression with an anxious/dysphoric temperament, which is also a complex mixed mood disorder, is the most likely diagnosis given the patient’s current symptoms. According to the scenario provided by Stahl Online (2018), the client has been experiencing a mixed dysphoric state with the depression occurring the majority of the time.

2. Bipolar II mixed episode:

Per the client’s history, he has been experiencing symptoms that are consistent with hypomania since the age of 23, such as inflated self-esteem, irritability, and decreased need for sleep (Stahl Online. 2018). Per the DSM 5, Bipolar II is defined as an abnormally elevated or irritable mood with an increased activity that lasts at least 4 uninterrupted days along with at least three behaviors such as inflated self-esteem, decreased need for sleep, increased talking, flight of ideas, racing thoughts, goal-driven activity, and participating in high-risk behaviors (American Psychiatric Association, 2013). Hypomanic episodes should also be noted by those close to the client per the DSM 5. Further interviewing with the client’s family needs to be completed in order to determine if the client exhibited hypomanic episodes. 

3. Primarily a cluster B personality disorder (antisocial/histrionic/narcissistic/borderline)

The client’s irritability, anxiety, and past failed relationships may be explained by a cluster B personality disorder, per the DSM 5. 

1.    ** 2 Pharmacological Agents: The medications of choice for this client would be those that aim at stabilizing the client’s mood, such as lithium or Lamictal. According to Stahl (2013), Lamictal is a second-line medication therapy that can be used to treat mixed state depression symptoms. The goal dosage of Lamictal would be 200 mg PO Daily. Lamictal dosages need to be titrated up slowly because of the serious side effect known as Steven Johnson’s Syndrome. Dosing Schedule: 25 mg PO daily for 2 weeks-50 mg PO Daily for 2 weeks- 100 mg PO Daily for 1 week-Double dose every week to maintenance at 200 mg Daily PO. Lithium is used for the maintenance treatment for manic-depressive conditions and major depressive disorder (Stahl, 2017). The main goal of treatment with lithium therapy is complete remission of symptoms (Stahl, 2017). The client should have initial kidney function tests done prior to starting therapy and 1 to 2 times a year during therapy. Serum lithium levels should be drawn every 1-2. weeks until the desired serum concentration is achieved, then every 2-3 months for 6 months (Stahl, 2017). After the first 6 months of lithium therapy, stable serum lithium levels should be drawn 1-2 times per year. I would choose Lamictal therapy over lithium therapy due to the lack of lab work needed to maintain and dose Lamictal, compared to lithium. 

**Dosing Considerations in Regard to Ethnicity

This particular client’s race was not identified in the case study. According to Prescribing Information (2005), Lamictal had an oral clearance that was 25% lower in non-Caucasians than Caucasians. If this patient were not Caucasian, he would most likely require a lower dose of Lamictal due to the 25% decrease in oral clearance. 

**Check Points

12 Week Follow Up: 

– The client discontinued his methylphenidate per PMHNP recommendation due to the increased risk of causing the client to have cycling unstable mood states.  

-The client started lamotrigine by his local psychiatrist, 400mg PO Daily. I would decrease this dose to 200mg PO Daily per current lamotrigine initiation recommendations (Stahl, 2013).

16 Week Follow Up:

– The client decided to discontinue his lamotrigine because it was making him more depressed and inhibiting his sex life. I would review the patient’s renal function and urinalysis and initiate lithium therapy in order to stabilize his mood. I would prescribe the patient 400mg PO QHS

20, 24, 28 Week Follow Up:

-The client’s lithium levels are 0.4, his dose finally increased to 1800 mg daily. The client unhappy with his lithium therapy due to it negatively affecting his Chron’s disease. The dose is titrated down to 1500mg of lithium and Lamictal therapy is restarted at 25mg and titrated to a max dose of 200mg, which was half of his initial dosage. The hope is that using two mood stabilizers will work together and produce therapeutic effects

– The client restarted methylphenidate therapy against medical advice. The client attested to restarting it because of his low energy and dysphoric mood.

32, 34, & 36 Week Follow Up:

-The client is non-compliant with prescribed medications and therapy and continues to disregard PMHNP recommendations

 **Lessons Learned and Ethical Considerations

This case study has taught me to always remember that difficult clients will inevitably be difficult to treat. There will be times when I will need to ask those who have more experience than me for help in deciding the appropriate course of treatment in certain challenging clients. I also learned that treating challenging clients will take time and results may not be observed for a while. It is important to give the specific choice of treatment time to work. One ethical consideration that I took away from this case study is that this patient is a physician, who has taken the liberty of making his own therapeutic decisions in the past. As a provider, I need to monitor and observe this client closely in case he chooses to self prescribe his own medications and disregard his care plan. 

                                                        References 

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author

Columbia-Suicide Severity Rating Scale. (2016). Retrieved December 9, 2019, from http://cssrs.columbia.edu/scoring_cssrs.html

Hirschfeld, R. M. (2002). The Mood Disorder Questionnaire (MDQ). Retrieved December 9, 2019, from 

     SAMHSA website: https://www.integration.samhsa.gov/images/res/MDQ.pdf 

Perscribing Information for Lamictal. (2005). Retrieved December 11, 2019, from FDA website: 

     https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/ 

     020241s10s21s25s26s27,020764s3s14s18s19s20lbl.pdf

 

Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY: Cambridge University Press

Stahl, S. M. (2017). The prescriber’s guide (6th ed.). New York, NY: Cambridge University Press

Tolliver, B. K., & Anton, R. F. (2015). Assessment and treatment of mood disorders in the context of 

     substance abuse. Dialogues in clinical neuroscience, 17(2), 181-190. 

     https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518701/ 

 

 
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Post Casey 19222135

Respond to the post bellow (positive comment), using one or more of the following approaches:

Ask a probing question, substantiated with additional background information, and evidence.

Share an insight from having read your colleagues’ postings, synthesizing the information to provide new perspectives.

Offer and support an alternative perspective using readings from the classroom or from your own review of the literature in the Walden Library.

Validate an idea with your own experience and additional sources.

Make a suggestion based on additional evidence drawn from readings or after synthesizing multiple postings.

Expand on your colleagues’ postings by providing additional insights or contrasting perspectives based on readings and evidence.

                                                          Main post

In order to improve patient outcomes and ensure appropriate decision making, it is essential that evidence-based practice (EBP) be incorporated into patient clinical experiences (Polit & Beck, 2017). EBP should be a priority in this current day and age of healthcare. Patient healthcare decisions should be designed according to the most up to date available clinical evidence. This clinical evidence should be focused on safe and efficient patient care. In many facilities, my own included, EBP is encouraged to be incorporated into daily clinical practice. Unfortunately, the practical process and resources that are necessary for achieving EBP are frequently not available or successful (Aitken et al., 2011). In order to improve and increase EBP utilization in healthcare, nurse-led EBP programs have been put in place. My current institution is currently trialing a nurse-led EBP in the ICU. This program consists of 3 nurses that complete daily rounds in the ICU to evaluate the efficacy of specific protocols or products such as oral care on ventilated patients being completed every 2 hours. 

According to Cullen & Adams (2012), nurse-led research is increasingly recognized as an essential pathway to effective and practical was of improving patient outcomes. The dissemination of EBP should be a top priority. Effective dissemination strategies provide a pathway for knowledge to be shared and inspire further innovations. In order to disseminate EBP findings, my institution uses its website to post the most current and up to date clinical findings. The healthcare staff members are expected to review newly posted information on a weekly basis. When it comes to instituting an excellence-focused culture in healthcare, nursing research and EBP are required along with the integration of a professional practice model (Aitken et al., 2011). In order to achieve this great feat, nurses and all healthcare staff alike need to be encouraged to participate in scholarly activities (Aitken et al., 2011). Healthcare institutions should also have readily available resources for nurses and staff members to investigate the most current EBP methods.  

 

Aitken, L. M., Hackwood, B, Crouch, S., Clayton, S., West, N., Carney, D., & Jack, L. (2011). Creating an environment to implement and sustain evidence-based practice: A developmental process. Australian Critical Care, 24(4), 244–254.

Cullen, L., & Adams, S. L. (2012). Planning for implementation of evidence-based practice. Journal of Nursing Administration, 42(4), 222–230.

Polit, D. F., & Beck, C. T. (2017). Nursing research: Generating and assessing evidence for nursing practice (10th ed.). Philadelphia, PA: Wolters Kluwer.

 
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Post Douglas

Respond  on two different days who selected different factors than you, in one or more of the following ways:

Offer alternative diagnoses and prescription of treatment options for osteoarthritis and rheumatoid arthritis.

Share an insight from having read your colleague’s posting, synthesizing the information to provide new perspectives.

                                                        Main Post

Rheumatoid arthritis and osteoarthritis both involve inflammation and affect the joints. Rheumatoid arthritis is a chronic systemic inflammatory disease characterized by the persistent symmetric inflammation of multiple peripheral joints (Hammer & McPhee, 2019). Osteoarthritis is characterized by local areas of loss and damage of articular cartilage, inflammation, new bone formation of joint margins, subchondral bone changes, variable degrees of mild synovitis, and thickening of the joint capsule (Huether & McCance, 2017).

Pathophysiology

Osteoarthritis is most commonly from wear and tear of the cartilage around the joint; this can be enhanced form sports or overuse at a particular occupation. Pro-inflammatory factors are released, and catabolic activation begins resulting in a net degradation of cartilage extracellular matrix (Esa et al., 2019). The cartilage becomes and may be absent over some areas, leaving the bone unprotected (Huether & McCance, 2017). Rheumatoid arthritis pathophysiology involves the destruction of the synovial linings that protect the joints; these linings provide nutrients and lubrication for the articular cartilage. Hammer and McPhee (2019) explain that enhanced pro-inflammatory cytokine production is a dominant feature of rheumatoid arthritis. 

Gender and Ethnicity’s Impact 

Rheumatoid arthritis is most typically a persistent, progressive disease presenting in women in the middle years of life (Hammer & McPhee, 2019). Studies have shown that hormones play a role in the development of rheumatoid arthritis, specifically when women are undergoing hormonal changes at childbirth and menopause. All these phenomena have in common an acute decline in ovarian function and/or in oestrogen bioavailability (Alpízar-Rodríguez, Pluchino, Canny, Gabay, & Finckh, 2016). The peak incidence in females coincides with menopause when the ovarian production of sex hormones drops markedly (Karsdal, Bay-Jensen, Henriksen, & Christiansen, 2012). No evidence supports that ethnicity is a factor in rheumatoid arthritis. Several studies performed, but due to their limitations and sample sizes, they could not be validated.

Although osteoarthritis incidence rates are quite similar in men and women, after age 50, women typically are more severely affected (Huether & McCance, 2017).  Following the same pattern as rheumatoid arthritis with menopausal and post-menopausal women. Several experimental studies have shown that estrogens are implicated in the regulation of cartilage metabolism (Mahajan & Patni, 2018). Again for osteoarthritis, no research clearly recognized that ethnicity enhanced the disease process. 

Conclusion

Both osteoarthritis and rheumatoid arthritis are the two most common forms of arthritis that affect millions of people. The symptoms can be very similar, and a thorough examination should be done to distinguish between the two. Osteoarthritis usually affects one joint, while rheumatoid arthritis affects several joints at once. 

                                                                                                                           References

Alpízar-Rodríguez, D., Pluchino, N., Canny, G., Gabay, C., & Finckh, A. (2016). The role of female hormonal factors in the development of rheumatoid arthritis. Rheumatology. https://doi-org.ezp.waldenulibrary.org/10.1093/rheumatology/kew318

Esa, A., Connolly, K., Williams, R., & Archer, C. (2019). Extracellular Vesicles in the Synovial Joint: Is there a Role in the Pathophysiology of Osteoarthritis? Malaysian Orthopaedic Journal, 13(1), 1-7. https://doi-org.ezp.waldenulibrary.org/10.5704/MOJ.1903.012

Hammer, G. D., & McPhee, S. J. (2019). Pathophysiology of disease: An introduction to clinical medicine (8th ed.). New York, NY: McGraw-Hill Education.

Huether, S. E., & McCance, K. L. (2017). Understanding pathophysiology (6th ed.). St. Louis, MO: Mosby.

Karsdal, M. A., Bay-Jensen, A. C., Henriksen, K., & Christiansen, C. (2012). The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: may estrogen be a magic bullet? Menopause International, 18(4), 139–146. https://doi-org.ezp.waldenulibrary.org/10.1258/mi.2012.012025

-org.ezp.waldenulibrary.org/10.4103/jmh.JMH_157_18doi(4), 171. https://9 Journal of Mid-life Health,, R. (2018). Menopause and Osteoarthritis: Any Association? Patni, A., & Mahajan

  Week 2 Discussion 2 Post.doc (59 KB) 

 
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