Consider the following case study:

Patient AO has a history of obesity and has recently gained 9 pounds. The patient has been diagnosed with hypertension and hyperlipidemia. Drugs currently prescribed include the following:

· Atenolol 12.5 mg daily

· Doxazosin 8 mg daily

· Hydralazine 10 mg qid

· Sertraline 25 mg daily

· Simvastatin 80 mg daily

To prepare:

• Review      this week’s media presentation on hypertension and hyperlipidemia, as well      as Chapters 19 and 20 of the Arcangelo and Peterson text.
• Select      one one the following factors: genetics, gender, ethnicity, age, or      behavior factors.
• Reflect      on how the factor you selected might influence the patient’s      pharmacokinetic and pharmacodynamic processes.
• Consider      how changes in the pharmacokinetic and pharmacodynamic processes might      impact the patient’s recommended drug therapy.
• Think      about how you might improve the patient’s drug therapy plan based on the      pharmacokinetic and pharmacodynamic changes. Reflect on whether you would      modify the current drug treatment or provide an alternative treatment      option for the patient.

With these thoughts in mind:

Post an explanation of how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study. Then, describe how changes in the processes might impact the patient’s recommended drug therapy. Finally, explain how you might improve the patient’s drug therapy plan.

– This work should have Introduction and conclusion

– This work should have at 3 to 5current references (Year 2012 and up)

– Use at least 2 references from class Learning Resources

The following Resources are not acceptable:

1. Wikipedia

2. Cdc.gov- nonhealthcare professionals section

3. Webmd.com

4. Mayoclinic.com

Required Readings

**Arcangelo, V. P., Peterson, A. M., Wilbur, V., & Reinhold, J. A. (Eds.). (2017). Pharmacotherapeutics for advanced practice: A practical approach (4th ed.). Ambler, PA: Lippincott Williams & Wilkins.

• Chapter 19, “Hypertension”      (pp. 257-272)
       This chapter examines the relationships between the cardiovascular,      nervous, and renal systems. It then describes diagnostic criteria for      hypertension patients, drugs used to treat hypertension and possible      adverse reactions, monitoring patient response, and patient education.
• Chapter 20, “Hyperlipidemia”      (pp. 275-286)
       This chapter explores causes of hyperlipidemia, treatments for      hyperlipidemia patients, and methods for monitoring patient response. It      also reviews strategies for risk assessment and patient education.
• Chapter 21, “Chronic Stable      Angina” (pp. 289-303)
       This chapter begins by exploring factors that contribute to chronic stable      angina, types of drugs used in treatment, and diagnostic criteria for      initiating drug therapy. It also examines methods for monitoring patient      response to treatment and educating patients on self-care.
• Chapter 22, “Heart Failure”      (pp. 305-322)
       This chapter examines the process of prescribing drugs to treat heart      failure and explores effects of prescribed drugs, proper dosages, and      possible adverse reactions.
• Chapter 50, “Pharmacotherapy      for Venous Thromboembolism Prevention and Treatment, Stroke Prevention in      Atrial Fibrillation, and Thromboembolism Prevention with Mechanical Heart      Valves” (pp. 863-886)

 This chapter covers drug therapy options for three disorders requiring anticoagulants: venous thromboembolism, atrial fibrillation, and ischemic stroke. It also explains the process of initiating and managing drug therapy for patients with these disorders.

**Drugs.com. (2012). Retrieved from http://www.drugs.com/

This website presents a comprehensive review of prescription and over-the-counter drugs including information on common uses and potential side effects. It also provides updates relating to new drugs on the market, support from health professionals, and a drug-drug interactions checker.

Required Media

Laureate Education, Inc. (Executive Producer). (2012). Hypertension and hyperlipidemia. Baltimore, MD: Author.

This media presentation outlines hypertension and hyperlipidemia including contributing factors, evaluation, treatment, and implications.

 

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Gastrointestinal (GI) and hepatobiliary disorders affect the structure and function of the GI tract. Many of these disorders often have similar symptoms, such as abdominal pain, cramping, constipation, nausea, bloating, and fatigue. Since multiple disorders can be tied to the same symptoms, it is important for advanced practice nurses to carefully evaluate patients and prescribe a treatment that targets the cause rather than the symptom. 

Once the underlying cause is identified, an appropriate drug therapy plan can be recommended based on medical history and individual patient factors. In this Assignment, you examine a case study of a patient who presents with symptoms of a possible GI/hepatobiliary disorder, and you design an appropriate drug therapy plan.

To Prepare

Review the case study assigned by your Instructor for this Assignment

Reflect on the patient’s symptoms, medical history, and drugs currently prescribed.

Think about a possible diagnosis for the patient. Consider whether the patient has a disorder related to the gastrointestinal and hepatobiliary system or whether the symptoms are the result of a disorder from another system or other factors, such as pregnancy, drugs, or a psychological disorder.

Consider an appropriate drug therapy plan based on the patient’s history, diagnosis, and drugs currently prescribed.

ASSIGNMENT: 

The case assignment for this week is as follows: 

Patient HL comes into the clinic with the following symptoms: nausea, vomiting, and diarrhea. The patient has a history of drug abuse and possible Hepatitis C. HL is currently taking the following prescription drugs:
• Synthroid 100 mcg daily
• Nifedipine 30 mg daily • Prednisone 10 mg daily

 

Write a 1-page paper that addresses the following:

Explain your diagnosis for the patient, including your rationale for the diagnosis.

Describe an appropriate drug therapy plan based on the patient’s history, diagnosis, and drugs currently prescribed.

Justify why you would recommend this drug therapy plan for this patient. Be specific and provide examples.

REQUIRED READINGS

Rosenthal, L. D., & Burchum, J. R. (2018). Lehne’s pharmacotherapeutics for advanced practice providers. St. Louis, MO: Elsevier.

Chapter 62, “Drugs for Peptic Ulcer Disease” (pp. 703–714)

Chapter 63, “Laxatives” (pp. 715–722)

Chapter 64, “Other Gastrointestinal Drugs” (pp. 723–735)

Chapter 78, “Antiviral Agents I: Drugs for Non-HIV Viral Infections” (pp. 867–886)

Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., . . . Sanya, A. J. (2018). The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology, 67(1), 328–357. Retrieved from https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.29367

This article details the diagnosis and management of nonalcoholic fatty liver disease. Review this article to gain an understanding of the underlying pathophysiology as well as the suggested pharmacotherapeutics that might be recommended to treat this disorder.

 

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Gastrointestinal (GI) and hepatobiliary disorders affect the structure and function of the GI tract. Many of these disorders often have similar symptoms such as abdominal pain, cramping, constipation, nausea, bloating, and fatigue. Since multiple disorders can be tied to the same symptoms, it is important for advanced practice nurses to carefully evaluate patients and prescribe treatment that targets the cause rather than the symptom. Once the underlying cause is identified, an appropriate drug therapy plan can be recommended based on medical history and individual patient factors. In this Discussion, you examine a case study of a patient who presents with symptoms of a possible GI/hepatobiliary disorder, and you design an appropriate drug therapy plan.

Consider the following case study:

Patient HL comes into the clinic with the following symptoms: nausea, vomiting, and diarrhea. The patient has a history of drug abuse and possible Hepatitis C. HL is currently taking the following prescription drugs:

· Synthroid 100 mcg daily

· Nifedipine 30 mg daily

· Prednisone 10 mg daily

To prepare:

· Review this week’s media presentation on pharmacology for the gastrointestinal system.

· Review the provided case study. Reflect on the patient’s symptoms, medical history, and drugs currently prescribed.

· Think about a possible diagnosis for the patient. Consider whether the patient has a disorder related to the gastrointestinal and hepatobiliary system or whether the symptoms are the result of a disorder from another system or other factors such as pregnancy, drugs, or a psychological disorder.

· Consider an appropriate drug therapy plan based on the patient’s history, diagnosis, and drugs currently prescribed.

With these thoughts in mind:

Post an explanation of your diagnosis for the patient including your rationale for the diagnosis. Then, describe an appropriate drug therapy plan based on the patient’s history, diagnosis, and drugs currently prescribed 

 

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Pharmacotherapy for Hematologic Disorders

In the 1970s, the average lifespan for patients diagnosed with sickle cell disease was 14 years. Today, the average lifespan has increased to 50 years and beyond (TriHealth, 2012). The patient prognosis for many other hematologic disorders such as hemophilia and cancer continue to improve as well. This can be attributed to advancements in medical care—specifically drug therapy and treatment. When managing drug therapies for patients, it is essential to continuously examine current treatments and evaluate the impact of patient factors on drug effectiveness. To prepare for your role as an advanced practice nurse, you must become familiar with common drug treatments for various hematologic disorders seen in clinical settings.

To prepare:

· Select one of the following hematologic disorders: anemia, hemophilia, cancer, sickle cell anemia, thalassemia, thrombolytic disorders, or white blood cell disorders. Consider the types of drugs that would be prescribed to patients to treat symptoms associated with this disorder.

· Select one of the following factors: genetics, gender, ethnicity, age, or behavior. Reflect on how this factor might impact the effects of prescribed drugs, as well as any measures you might take to help reduce negative side effects.

With these thoughts in mind:

write Plz include sub heading when writing

· a description of the hematologic disorder you selected including types of drugs that would be prescribed to patients to treat associated symptoms. (I am looking for an explanation at the cellular or molecular level (whenever possible).

· Then, explain how the factor you selected might impact the effects of prescribed drugs, as well as any measures you might take to help reduce negative side effects.

) I am looking for an explanation at the cellular or molecular level (whenever possible).

Points to follow when writing a paper:

Ø Please all bullets points, bold, red and highlighted area must be attended to. 

Ø A clear purpose statement (The purpose of this paper is to…) is required in the introduction of all writings. 

Ø Please review all rubrics.

Ø Check APA format/setting.

Ø Your final paragraph should be a summary of the key points of your paper.

Ø Please personalized where necessary.

In the 1970s, the average lifespan for patients diagnosed with sickle cell disease was 14 years. Today, the average lifespan has increased to 50 years and beyond (TriHealth, 2012). The patient prognosis for many other hematologic disorders such as hemophilia and cancer continue to improve as well. This can be attributed to advancements in medical care—specifically drug therapy and treatment. When managing drug therapies for patients, it is essential to continuously examine current treatments and evaluate the impact of patient factors on drug effectiveness. To prepare for your role as an advanced practice nurse, you must become familiar with common drug treatments for various hematologic disorders seen in clinical settings.

To prepare:

· Select one of the following hematologic disorders: anemia, hemophilia, cancer, sickle cell anemia, thalassemia, thrombolytic disorders, or white blood cell disorders. Consider the types of drugs that would be prescribed to patients to treat symptoms associated with this disorder.

· Select one of the following factors: genetics, gender, ethnicity, age, or behavior. Reflect on how this factor might impact the effects of prescribed drugs, as well as any measures you might take to help reduce negative side effects.

With these thoughts in mind:

write Plz include sub heading when writing

· a description of the hematologic disorder you selected including types of drugs that would be prescribed to patients to treat associated symptoms. (I am looking for an explanation at the cellular or molecular level (whenever possible).

· Then, explain how the factor you selected might impact the effects of prescribed drugs, as well as any measures you might take to help reduce negative side effects.

) I am looking for an explanation at the cellular or molecular level (whenever possible).

Points to follow when writing a paper:

Ø Please all bullets points, bold, red and highlighted area must be attended to. 

Ø A clear purpose statement (The purpose of this paper is to…) is required in the introduction of all writings. 

Ø Please review all rubrics.

Ø Check APA format/setting.

Ø Your final paragraph should be a summary of the key points of your paper.

Ø Please personalized where necessary.

 

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