I have Ch.1 review homework with 12 questions due on 12/2/18. Ch.4 review homework 56 questions multiple attempts. Ch. 4 review quiz 21 questions with 3 attempts. Ch. 4 assignment is due on 12/9/2018. These are not multiple choice questions.

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Colon cancer is something that two people in my life have had and have also died from. They were completely different in every way. One of the people was a 24-year-old female that worked as a firefighter for two years at the time of her diagnosis. She had no family history of colon cancer and did not drink alcohol or use tobacco products. Her only symptom was unexpected weight loss. The other was a 50-year-old male with no family history of the disease but drank alcohol and smoked cigarettes regularly. He was diagnosed shortly after having his first routine colonoscopy. He was asymptomatic. They both died within two years after their diagnosis. 

Genetics: Alterations and Symptoms

Genetics can play a role in having colon cancer because “hereditary nonpolyposis colorectal cancer is the methylation of a gene whose protein product repairs damaged DNA” (Huether & McCance, 2017, p. 52). The damaged DNA leads to the presence of tumors in the colon (Huether & McCance, 2017). Certain behaviors can alter a patient’s DNA over time like continuous predisposal to alcohol and tobacco products, along with many other risk factors (Huether & McCane, 2017). Someone that has ulcerative colitis is also more likely to acquire colon cancer (Huether & McCane, 2017).

Symptoms of colon cancer include weight loss, diarrhea, gastrointestinal bleeding, fever, abdominal pain, bowel obstructions, and/or bowel perforation (Hammer & McPhee, 2019). Patients can have all these symptoms or few (Hammer & McPhee, 2019).

Pathophysiology of the Disease and Cellular Function

When a patient acquires colon cancer many mutations in the DNA begin to accumulate, altering colon cells (Huether & McCane, 2017). The first mutation that begins to take place is when the Adenomatous polyposis coli (APC) gene is changed (Hammer & McPhee, 2019). This gene suppresses tumors and is present in the colon of those with mutation-free DNA (Huether & McCane, 2017). Protein glycosylation is altered when a tumor is formed (Zhang & Hagen, 2018). “O-linked glycosylation (GalNAc-T6) in the cellular transformations typically (is) seen in cancerous cells and tissues” (Zhang & Hagen, 2018, p. 1315). Zhang and Hagen performed a study where they discovered the O-linked protein was absent in cancer-free colons but was present in most colons infected with cancer (2018),

In a patient with colon cancer, somatic changes take place in the APC gene, and once polyps in the colon are formed, other pathways are alerted making the polyps begin to grow larger (Hammer & McPhee, 2019). The cell cycle allows cancer to progress because certain genes and apoptosis have been inactivated (Hammer & McPhee, 2019). In the normal cellular function of the colon, apoptosis kills off mutated DNA because it is not recognized, but with colon cancer, mutations multiply without any cell death (Hammer McPhee, 2019). Metastasis of colon cancer then takes place (Hammer & McPhee, 2019). 

References

Hammer, G. D., & McPhee, S. J. (2019). Pathophysiology of disease: An introduction to clinical medicine (8th ed.). New York, NY: McGraw-Hill Education.

Huether, S. E., & McCance, K. L. (2017). Understanding pathophysiology (6th ed.). St. Louis, MO: Mosby.

Zhang, L., & Hagen, K. G. T. (2018). Pleiotropic effects of o-glycosylation in colon cancer. Journal of Biological Chemistry, 294(4), 1315–1316. https://doi-org.ezp.waldenulibrary.org/10.1074/jbc.H117.812826

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In this week’s discussion assignment (Week 3 Discussion) you identified a career for a research topic and did some searching to find credible information. Now it is time to gather your thoughts and resources and structure them into a Microsoft Word document. You will write a summary about your research topic and the resources you have identified. With this assignment, you are introduced to formatting papers in the style that will be required in most of your future coursework.

Create a new Microsoft Word document and save it with the title of W3P_LastName.docx. Save this document in your ITS1000 folder on your computer (in which you saved your previous assignments). The Microsoft Word document should include the following.

• A Title page in APA format.
• The body of the paper containing one paraphrased paragraph from each of the four sources that you found for Week 3 Discussion. Double space the body of your paper and use an APA-styled in-text citation for each paragraph. There is no need to include the quoted paragraphs here; only include your paraphrasing and in-text citation for each source.
• An APA-formatted running header and page numbers.
• References page containing four APA-styled citations for the sources you paraphrased in the body of the paper.

Make sure you put the research findings into your own words, paraphrasing and citing your sources where appropriate.

Here is an example for a reference of a Web site address:
Author, I. (Last edited date). Title of resource. Retrieved from http://Web address

Submit your completed document to the appropriate submission folder by the due date assigned.

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Rate yourself using the results from the “Nurse Manager Skills Inventory”:

http://www.aone.org/resources/nurse-manager-skills-inventory.pdf

Write a reflection of 750-1,000 words in which you identify your strengths and weaknesses related to the four content areas below:

1. Personal and professional accountability
2. Career planning
3. Personal journey disciplines
4. Reflective practice reference behaviors/tenets

Discuss how you will use your current leadership skill set to advocate for change in your workplace.

Identify one personal goal for your leadership growth and discuss your implementation plan to achieve that goal.

While APA format is not required for the body of this assignment, solid academic writing is expected and in-text citations and references should be presented using APA documentation guidelines, which can be found in the APA Style Guide, located in the Student Success Center.

This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.

You are required to submit this assignment to Turnitin. Please refer to the directions in the Student Success Center.

 30.0 %Identification of strengths and weaknesses related to the four content areas listed. 

 25.0 %Discussion of use of current leadership skills to advocate change in the workplace 

 25.0 %Reflection on personal goal for leadership growth and development of implementation plan to reach goal. 

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Rate yourself using the results from the “Nurse Manager Skills Inventory”:

http://www.aone.org/resources/nurse-manager-skills-inventory.pdf

Write a reflection of 1,000 words in which you identify your strengths and weaknesses related to the four content areas below:

1. Personal and professional accountability
2. Career planning
3. Personal journey disciplines
4. Reflective practice reference  behaviors/tenets

Discuss how you will use your current leadership skill set to advocate for change in your workplace.

Identify one personal goal for your leadership growth and discuss your implementation plan to achieve that goal.

APA format is required for the body of this assignment, solid academic writing is expected and in-text citations and references should be presented using APA documentation guidelines.

NO PLAGIARISM PLEASE, MINIMUM OF 3 REFERENCES

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