Hi, need to submit a 5000 words paper on the topic Human Genome Project Using PCR. Annexin A5 is a classical member of the chordate annexin family. It displays essential tetra structure and calcium-dependent phospholipid binding. It is one of the few annexins that can be found within the extracellular matrix. Annexin A5 has been postulated to be an inhibitor of coagulation due to its ability to attach to anionic phospholipids exposed of surfaces of platelets (Gerke & Moss, 2010). Consequently, this important gene inhibits platelet aggregation and down regulates surface presentation of tissue factor. The annexin A5 gene covers approximately 9 kb of the human chromosome 4q27. It comprises of one non-translated exon and 12 coding exons. Little is known about the regulation of the annexin A5 gene expression. Annexin A5 is an abundantly and ubiquitously expressed protein with highest concentrations in the liver, placenta and kidney. The human annexin A5 gene produces numerous transcripts and has a complex promoter which is subject to intricate regulation mechanism (Gerke & Moss, 2010).
Annexin A5 has been implicated in a wide range of disease phenotypes and etiology including recurrent pregnancy losses and cancer. It is a calcium and phospholipid protein localized within the surface of the placental syncytiotrophoblast layer. This protein performs vital anticoagulant function within the maternal blood and specifically at the intervillous space. Recently, it has been reported that polymorphisms in the promoter region of the annexin A5 gene can significantly be linked to recurrent pregnancy loss (RPL). Particularly, women who possess the M2 haplotype have more than two-fold higher risk of fetal loss compared to non-carriers (Bogdanova, Horst, Chlystun, Croucher, Nebel, Bohring, et al. 2010).
Additionally, annexin A5 has been reported to be a vascular anticoagulant-?, placental anticoagulant protein I, liporcotin V, endonexin II, anchorin CII and placental protein 4. The annexin A5 gene spans 29 kilobases and has 13 exons which encode a single transcript of approximately 1.6 kb. The protein product of this gene has a molecular weight of approximately 35 kDa (Carcedo, Iglesias, Bances, Morgan & Fernandez, 2011). Official name of the gene: annexin A5 Official symbol: ANXA5 Gene type: protein coding Other names: PP4, ANX5, ENX2, RPRGL3 Chromosomal location: 4q27 (http://www.ncbi.nlm.nih.gov). Annexin A5 is a classical member of the chordate annexin family. It displays essential tetra structure and calcium-dependent phospholipid binding. It is one of the few annexins that can be found within the extracellular matrix.
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Hi Need To Submit A 5000 Words Essay On The Topic Oral Language And Code Related
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic Oral Language and Code-Related Precursors to Reading.
Juan describes his interests as playing basketball, swimming, and fishing, which he normally undertake with his family, particularly his father and brother. He claims to have a big difficulty in school though, specifically in reading and writing English words. He says that way back in Mexico, he used to appreciate Science, but right now where every subject matter including Science needs to be learned and understood in the English language, he begins to dislike the subject matter. He has average scores in Math concepts exhibited by his scores in quizzes and long examinations. He is however poor in word attack and English vocabulary, which affects his performance in other subjects including Science, which used to be his favorite.
 .I was able to talk to Juan’s aunt once, upon visiting Juan and gathering information from his family about things related to his reading progress. This is where I found that both of Juan’s parents live in Mexico and had little schooling. The aunt related that both boys frequently scan their notes upon arriving home and practice reading orally. However, there are some questions that she could not answer, such as the correct pronunciation of a word or the meaning of a particular word, or if the sentence the boys have just uttered is grammatically correct, since she herself has a limitation in the English language as she just migrated to the United States five months ago. Juan is thus left with only the school to rely on when learning to read.
 .Juan appears to be persevering during reading sessions and tries hard to understand each word. Often, when he could not pronounce a word, he approaches me and asks how it is pronounced. He repeatedly utters the new-learned word until he thinks it sinks in.
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Hi Need To Submit A 5000 Words Essay On The Topic Retroanalyses Nonrandomized St
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic Retroanalyses nonrandomized study over a X period of time for esophageal cancer patient which compares two treatment options: intra-luminal brachytherapy alone vs. intra-luminal brachytherapy treatment combined with chemotherapy.
Esophageal cancer is a very devastating disease (Gibson et al. 1564). This among others is factors that championed for the reason and purpose of this research study.
Although esophageal cancer may be cured in some patients, esophageal cancer treatment is very protracted. It decreases the quality of the life of the victim and is often lethal in several cases. The idyllic treatment of esophageal cancer is actually debatable. In fact, some defendants of surgical treatment have argued that resection is the only modality treatment to provide curative intent. however, the defendant of non surgical approach have claimed that esophageal cancer is particularly incurable and that esophagectomy pose a prohibitive index of mortality. Adenocarcinoma of the esophagus which is specifically different from the squamous cell carcinoma has effects on the distal esophagus of the patients and is normally detected in its initial stages. These facts about esophageal cancer has altered the natural history of surgical treatment in the population of young patient, making its cure a reality. Historically, there has been a well description of esophageal carcinoma since the early 19th Century. The first resection that was successful was conducted by Frank Torek in 1913. This was followed by Ohsawa and Marshall who performed the first transthoracic esophagectomy in Japan and united States respectively with the reconstruction of the continent (Van Cutsem et al. 14991).
According to recent studies, 90% of esophageal cancers are advanced locally at diagnosis, and its treatment brings about discouraging results. The rate of high dose brachytherapy (HDR-BT) allows an increment of the local doses with no particular significant toxic increment. Esophageal cancer has continued to pose a threat globally to the health of the public. The commonly witnessed practice is radiochemotherapy for unresectable tumors that have
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Hi Need To Submit A 5000 Words Essay On The Topic Sustainable Practices In Facil
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic Sustainable Practices in Facilities Management : Carbon Footprints.
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This development increases the implementation of the new techniques and equipments in all the sectors, which lead to increase in the level of pollution and most importantly carbon emission. Meanwhile, it is also true that with the growing level of pollution, several anti-pollution techniques and equipments have also been discovered through the improved technology. It is apparent that global risk is increasing with the transformation in the climate and it requires urgent response otherwise environmental destruction cannot be stopped. This fact has been accepted by several countries worldwide and they made commitments accordingly. Though it has already been discussed regarding the availability of the anti-pollution techniques, implementation of those techniques and equipments in an organization require long term planning in terms of financial, technological, human resource and other aspects. Considering this fact, it has been intended to prepare a report on the requirement of reducing carbon footprint in a construction company, named Building Blocks I LLC, strategy development and implementation process of the total carbon footprint. Moreover, the report will also provide recommendation of adopting the most suitable renewable energy technologies with the proper justification of the selection. Discussion Critical Analysis of the Causes of Generating Carbon Footprint Carbon footprint is the tool of measuring the total greenhouse gas emission that can be directly or indirectly generated from an individual, organization, products or events. The footprint consisted of all six components of Kyoto Protocol Greenhouse gases namely Methane (CH4), Carbon Dioxide (CO2), Hydro fluorocarbons (HFCs), Sulphur Hexafluoride (SF6), Nitrous Oxide (N2O) and Per fluorocarbons (PFCs). Carbon footprint can be measured in the tones of ‘carbon dioxide equivalent’, which can be symbolized as (tCO2e). Carbon footprint can be classified into two forms namely organizational and product. Organizational carbon footprint considers all the emissions from the activities across the organization, which includes company vehicles, industrial processes and energy use of buildings. Wherein, emissions across the entire product and service life cycle are considered as the product’s carbon footprint. It engaged manufacturing right, extraction of raw material, its use, final reuse, disposal and eventually recycling (Carbon Trust, 2011). From each and every day-to-day activities of an organization or a household, greenhouse gases can be generated, which have massive contribution in the overall carbon emission. The sources of carbon footprint can be exhibited through a diagram. Source: (Carbon Footprint, 2011).
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Hi Need To Submit A 5000 Words Essay On The Topic Targeting Voters In The Digita
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic Targeting Voters in the Digital Age.
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Both Obama campaigns of 2008 and 2012 are mirrored images of how voters are targeted in the digital age through social media. A popular opinion is that while the Obama campaign lead because of high interaction with the public and through extensive incorporation of social media and other creative applications, others candidates did not quite manage to adequately engage in dialogue with their voters. The candidates usually go all the way through to make use of the communications technology in the present age to get in the good books of the voters they target which is different from how they used to seek votes in the past age when communications technology and social media were not as powerful as they are now. This research paper basically attempts to scrutinize with the help of research literature how the voters are reached in the digital age, how this digital mania influences campaigns, why the Obama campaigns led over others when delivering their message, and how this whole process is different from the way campaigns operated some decades before. Like other daily tasks of life are positively influenced by digital technology for example, the ease of depositing bills with our smartphones and listening to the candidates’ speeches online whenever feasible, the political process has also tasted the exciting taste of the digital technology. Both elections of 2008 and 2012 mad extensive use of social media and while “in 2008, there were about 1.5 million election-related tweets, in 2012 there were 31 million” (Jeffers). It is worth appreciating how through different riveting digital applications the political process is brought into the 21st century and made all the more exciting and comfortable at the same time. The electoral process is made modernized by the digital age and both digital technology companies and political candidates are set out to further modernize this process through employment of latest technologies available. There are many voting applications out there in the market presently which allow voters to find the required information about their voters and cast their donations directly to their favorite candidates with one single tap on the touchscreen. According to NYC Votes, voting is a very important ritual and it is their responsibility to bring all facets of the electoral process into the digital age by introducing new applications (Vanhemert). NYC Votes for this purpose has introduced two new applications, mobile web app which is a contribution tool and allows the voters to cast their donations to the candidates and lets the latter collect all donations on their smartphones and Voter Engagement tool which enables voters to find all they want to about the candidates, make donations, and much more. These kinds of things make the political process of elections seem very different to how the candidates reached voters in the past age when nothing was so modernized and all tasks of the electoral process were painfully time-consuming. Research shows that one of the main reasons Obama presidential campaigns led over those run by Mitt Romney was that people behind the Obama campaigns took the power of digital applications like Facebook and Twitter really seriously and used them to their advantage in any way they could. Social media should not only be considered a change in technology as it is really a change in the public’s tendency to communicate (Jeffers).
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Hi Need To Submit A 5000 Words Essay On The Topic The Digital Music Market Apple
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic The Digital Music Market: Apple iTunes.
Apple iTunes’ market entry strategy into the UK is more likely to succeed if carried out with much more concentration on customer satisfaction and value creation fronts while at the same time focusing on a market penetration pricing strategy coupled with incremental growth strategies in niche market centric operations.
 .Operated and managed by Apple Inc. the iTunes Store is a software-based online digital media store. It was opened as the “iTunes Music Store” on April 28, 2003 (www.images.apple.com). According to a research study conducted by London based researcher Xtn Data, it was mentioned that Apple’s iTunes Music store has a larger share of the UK digital music download market than the sum total of its competitors put together, i.e. accounting for about 54% of the market. It has been reported that as the demand for digital music has increased along with Apple’s market share (www.apple/tunes.com).
 .Apple maintains a good brand image. Thus it has a loyal customer base that helps to recruit new customers and to retain them. Thus its customers are enticed to buy new products such as iTunes when it was introduced (Dunmore, 2008).
 .There is tremendous pressure on Apple from the music industry itself to increase the price of its music downloads. This is because as digital music has become popular the music industry makes more money from iTunes (i.e. downloadable music files) than from their original CD sales. So far the company has not given in to this pressure, but if it gives in, it will be seen as a commercial weakness.
 .Apple has had a long-standing contractual relationship with IBM to supply it with chips. In early 2005 Apple threatened to terminate this relationship, and switch on to IBM’s rival Intel. Some industry people are of the opinion that this change could confuse Apple’s customers (Hart-Davis, 2009).
 .
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Hi Need To Submit A 5000 Words Essay On The Topic The Effect Of The Goodwill Amo
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic The Effect of the Goodwill Amortization on the Informative of Earnings.
The paper also focuses on particular examples and analyses the differences caused by the changed guidelines by considering many literature reviews and statistics. Further, it takes into account a data set that provides information about certain performance measures of the companies. Taking the hypothesis that the information content of the income without the extraordinary items is something that is significantly equal to the income that is generated after the exclusion of the goodwill amortization, the data is used to generate empirical results to prove the hypothesis. Through the results and through the performance measures deductions are made about the information contents of the variables use. Hence the paper basically, in the end, tries to prove how the exclusion of the goodwill amortization affects the informative of the earnings of certain companies. Although the data set is a limited one (having a hundred observations only), yet it does seek to prove the hypothesis. The results of the income before the extraordinary items are compared to the income after the exclusion of the goodwill amortization and the net cash flow from observations to find the relative content ranking of all three. The paper also provides explanations for the results that may not seem to be accurate and tends to question if the substitution of the income after the exclusion of goodwill amortization for the income before extraordinary items undertaken by the FASB was a proper step,
In 2001, according to a report by the Working Council for Chief Financial Officers (2002), the FASB adopted the Statement of Financial Accounting Standards (SFAS) No.142 Goodwill and Other Intangible Assets which meant that a new set of rules were introduced to deal with the accounting information related to the goodwill amortization. The statement proposed that the goodwill and the intangible assets had an infinite life and so there was no need for the amortization of such assets, as Choi .and Federick (2003) relate.
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Hi Need To Submit A 5000 Words Essay On The Topic The Uk Hotel Industry In Spite
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic The UK Hotel Industry.
In spite of such diversity, a large proportion of work in the manufacturing industries to relates services. (Hoque 1999b). While human resources management as a concept attracted a lot of attention as a “more effective and productive approach to managing organizations key assets, its people”, there have been differences of opinion as to whether it is industrial relations management-personnel management (IR & PR) freshly packaged or a totally different discipline “aimed at integrating the management of people into overall business strategy and organizational goals” (Poole, 1990. Salamon, 1987. Storey, 1995b cited in Mc Gunnigle 2000). Three models of HRM have been suggested: normative” (prescriptive of an ideal approach). “descriptive” (identifying developments and practice in the field). and “conceptual” (a model for classification). (Storey 1992 cited in Mc Gunnigle 2000). In the normative model, HRM has a “team development” orientation, a “significant role for line managers” and seeks to develop an “organizational culture”. The conceptual model differs widely from IR-PR with as many as 27 differences listed. All researchers, however, agree that employee commitment is not only the dominant aspect of HRM but that it is the main differentiator between HRM and IR-PR. (Storey 1992 and Guest 1995 cited in Mc Gunnigle 2000).
 .The objective of human resource management is fostering employee commitment to enhancing employee performance. The rationale behind this premise is that employee commitment makes them more satisfied, productive, adaptable, willing to accept organizational goals and values and not mind to ‘stretch’ to meet these goals. ‘Stretch’, in this context refers to additional productivity, effective contributions and taking part in continuous improvement processes.
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Hi Need To Submit A 5000 Words Essay On The Topic Wgst400 Assignment 4 In France
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic WGST400 Assignment 4.
In France and England, women have played vital roles during the First World War, and such roles have helped secure victories for the Allied Forces. The thesis statement for this paper is: The participation of French and British women during the First World War laid out the foundation for improved rights for these women following WWI. Empowered women in France and England helped initiate and advance the cause for the First World War and for contemporary feminism. This paper shall first discuss the role of women in France and England during the First World War. It shall then move on to discuss how these women helped advance the cause of the feminism and then of the First World War. A final discussion on how these women have contributed to the causes of contemporary feminism shall also be presented. This study is being carried out in order to help understand feminism within the context of the First World War in France and England. It also seeks to develop a better understanding of the current state of feminism and its development throughout the years.
During the First World War, women in France and England played various roles. In France, the women assisted in the war efforts and activities, but mostly as individuals or as members of private organizations1. The French government did not want to mobilize and militarize their women because the French government did not recognize these women as citizens who also had their roles to play in the well-being of the country2. The government believed that if the French women would be militarized, then they were also full-fledged citizens of the country. This would imply that there was a need for the French government to also recognize the civic and suffrage rights of the women3. Allowing women to participate in the war efforts was also seen by the French government as a major threat to the gender construct in their country. Wars and the military
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Hi Need To Submit A 5000 Words Essay On The Topic What Are The Organisational Be
/in Uncategorized /by developerHi, need to submit a 5000 words essay on the topic What are the organisational benefits of performance review.
While these individuals may differ on how and when performance reviews should be conducted they are all united on the point that such reviews and the review process itself is an essential part of employee growth which in turn leads to the growth of the company. Jack Welch served as the CEO of General Electric for more than two decades and links performance reviews to the overall mission of the company.
Welch (2005, Pg. 16) says that “Every decision or initiative was linked to the mission. We publicly rewarded people who drove the mission and let go of people who couldn’t deal with it for whatever reason.” GE’s own mission, when Welch was running the company, was to be the most competitive company in the world which fits with the two pronged approach of rewarding and doing the utmost to keep the best talent within the company and letting go of those who do not perform to a certain level. Such tactics could only be employed when effective performance review processes are in place and GE’s system for performance reviews has been lauded by critics and copied verbatim by the competition simply because it is one of the best.
The current issues faced by our organisation are mostly concerned with the human resource management of the company. Before an outline of these issues as well as a discussion of the problems is made, it must be noted that none of these issues are large enough to cripple the company but they do make the management process more difficult. Additionally, all these issues come with simple solutions and if those solutions are applied with careful consideration there should be no reason why the company can not gain competitive advantages over time.
The central issue for the company comes from the fact that many of our senior managers and other personnel have little or no formal training in management which leads to a lack of
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Hi Need To Submit A 5000 Words Paper On The Topic Human Genome Project Using Pcr
/in Uncategorized /by developerHi, need to submit a 5000 words paper on the topic Human Genome Project Using PCR. Annexin A5 is a classical member of the chordate annexin family. It displays essential tetra structure and calcium-dependent phospholipid binding. It is one of the few annexins that can be found within the extracellular matrix. Annexin A5 has been postulated to be an inhibitor of coagulation due to its ability to attach to anionic phospholipids exposed of surfaces of platelets (Gerke & Moss, 2010). Consequently, this important gene inhibits platelet aggregation and down regulates surface presentation of tissue factor. The annexin A5 gene covers approximately 9 kb of the human chromosome 4q27. It comprises of one non-translated exon and 12 coding exons. Little is known about the regulation of the annexin A5 gene expression. Annexin A5 is an abundantly and ubiquitously expressed protein with highest concentrations in the liver, placenta and kidney. The human annexin A5 gene produces numerous transcripts and has a complex promoter which is subject to intricate regulation mechanism (Gerke & Moss, 2010).
Annexin A5 has been implicated in a wide range of disease phenotypes and etiology including recurrent pregnancy losses and cancer. It is a calcium and phospholipid protein localized within the surface of the placental syncytiotrophoblast layer. This protein performs vital anticoagulant function within the maternal blood and specifically at the intervillous space. Recently, it has been reported that polymorphisms in the promoter region of the annexin A5 gene can significantly be linked to recurrent pregnancy loss (RPL). Particularly, women who possess the M2 haplotype have more than two-fold higher risk of fetal loss compared to non-carriers (Bogdanova, Horst, Chlystun, Croucher, Nebel, Bohring, et al. 2010).
Additionally, annexin A5 has been reported to be a vascular anticoagulant-?, placental anticoagulant protein I, liporcotin V, endonexin II, anchorin CII and placental protein 4. The annexin A5 gene spans 29 kilobases and has 13 exons which encode a single transcript of approximately 1.6 kb. The protein product of this gene has a molecular weight of approximately 35 kDa (Carcedo, Iglesias, Bances, Morgan & Fernandez, 2011). Official name of the gene: annexin A5 Official symbol: ANXA5 Gene type: protein coding Other names: PP4, ANX5, ENX2, RPRGL3 Chromosomal location: 4q27 (http://www.ncbi.nlm.nih.gov). Annexin A5 is a classical member of the chordate annexin family. It displays essential tetra structure and calcium-dependent phospholipid binding. It is one of the few annexins that can be found within the extracellular matrix.
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