Hi, I need help with essay on Using one example of a cellular oncogene, illustrate molecular mechanisms of activation and the consequences for protein function; for this specific example, also provide information about the occurrence in cancer and any current treatments. Paper must be at least 500 words. Please, no plagiarized work!
The oncogene is also involved in the regulation of diverse behaviors of the cell as part of the larger Ras protein super-family. Their signaling activity results in the growth and division of cells, which means that over-activity on the oncogene’s part, will ultimately cause cancer (Hanahan & Weinberg 2011, p. 654). In fact, the Ras oncogene is the most common in cancer with over 20% of all human cancers possessing permanent Ras mutations and 90% in some cancers like pancreatic cancer. Therefore, inhibitors of the Ras oncogene have been studied in the search for cancer treatment.
Ras is a protein that binds guanosine nucleotides and is referred to as G-protein. As with other G-proteins, Ras functions as a binary signaling switch with binding of GTP switching it on, while binding of GDP acts to switch it off. The additional phosphate functional group ensures that the switch regions are configured as a loaded spring at Gly-60 and Thr-35 (Weinberg 2013, p. 115). Therefore, the cycling between inactive GDP and active GTP molecules controls the deactivation and activation of the Ras oncogene. Exchange between these molecules is, in turn, facilitated by GEF and GAP molecules, of which GEF promotes the release of GDP and attachment of GTP to the Ras oncogene. Examples of GEF’s include cdc25 and Son of Sevenless (Bock & Marsh 2010, p. 65).
The GEF protein catalyzes the release of GDP by inserting near the binding sites for Mg+ and the P-loop, thus inhibiting their interaction with P-. Within the P-loop, a lysine group is pulled away from GDP by negative residues, increasing the distance between switch I and guanine, and breaking the contact between GDP and Ras (Bock & Marsh 2010, p. 65). Since there is an abundance of activated GTP molecules in the cell, it predominantly binds to the Ras molecule’s nucleotide binding site. In this configuration, the oncogene has heightened
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Hi I Need Help With Essay On Understanding Primary Paper Must Be At Least 500 Wo
/in Uncategorized /by developerHi, I need help with essay on Understanding Primary. Paper must be at least 500 words. Please, no plagiarized work!
Understanding Primary Research
My goals for doing this primary research are determining that there is indeed a vandalism problem and that there are not enough solutions so far from the University and the police, so I need to find better solutions for it, and finding feasible recommendations for an anti-vandalism recommendations report. This primary research will help me determine solutions to vandalism and in finding the most feasible option.
I believe that this research will improve the campus’ knowledge on vandalism’s prevalence and what target audiences think about the effectiveness of existing solutions. I also believe that this will motivate stakeholders into identifying and supporting new solutions to vandalism by finding offender-centered and environment-related solutions.
I will accomplish my goals by ensuring that I interview the right audiences who can give me relevant information about vandalism efforts in the campus and how they can be improved. I will interview three senior students, one teacher, Gloria Aparicio Blackwell, Director of Community Engagement, Andrea Goodwin, Director of Student Conduct, and MPO Robert Jenshoej of the campus police. Besides this interview, I will also conduct a survey in class regarding the prevalence, motivations, and resolutions to vandalism in the campus. I will ask another teacher and student first for the pilot testing of the interview and survey questions to improve my instruments’ usability, validity, and reliability.
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Hi I Need Help With Essay On Understanding The Product Drug Familiarization Pape
/in Uncategorized /by developerHi, I need help with essay on Understanding the Product: Drug Familiarization. Paper must be at least 500 words. Please, no plagiarized work!
However, the lethal side effects of the drug were not established in pre-clinical tests conducted before the drug was declared safe for human use (Tim 42). Accutane is the most popular brand of Isotretinoin and hence the most destructive according to statistics. Although the side effects of the drug have been proved beyond reasonable doubt, the drug is still in the shelves of most United States’ pharmacies. Despite the side effects, the drug is among the most effective in the family of drugs applied in the treatment of cancer ( Wysowski, Pitts, and Beitz 43). This is the main factor that has enhanced continuous use of the drug. Successful usage of the drug depends on the probability of developing medical complications, which vary between individuals.
Isotretinoin is regarded as the most dangerous drug in the country since it not only affects an individual but also an entire generation (FDA Web). This is because the reactions of the human body to the drugs are passed through birth or are inherited. In most cases, an individual may have dormant response to the drug. In such cases, a person will have invisible reactions after undergoing a treatment using the drug. However, the consequences of the drug may be propagated through birth leading to serious complication to children whose parents had used the drug. Babies born to parents who had previously used the drug are born with serious complication in their nervous system that leaves them incapacitated throughout their lives.
The drug not only has lethal side effects on the offspring of its users but it also affects current users. Studies carried out in Texas on users indicated that a user was 75% likely to develop cardiac problems compared to a person who have never used the drug ( Wysowski, Pitts, and Beitz 23). It was also established that users were more likely to suffer irreversible brain damage after their first dose. This indicates that the drug has
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Hi I Need Help With Essay On Unionizing Chinese Walmart Store Paper Must Be At L
/in Uncategorized /by developerHi, I need help with essay on Unionizing Chinese Walmart Store. Paper must be at least 1000 words. Please, no plagiarized work!
Wal-Mart has had a resistance of unions in most of the countries but has allowed the formation of unions in China. The largest retailer in the world, which employs close to 23,000 people in China, will allow the federation to form branches in all the outlets in China. The world retailer was under pressure from the other unions that claimed that the company contributed much to a violation of human rights job losses when it carries its operations in China. This was because the United States employees are not under unions. The unions also were formed to meet the demands of the Chinese government that allows unions to have a formal establishment. The formation, however, has not translated to any effective bargaining power of the employees, which was the main aim of forming the unions. The retailer claimed that instead of forming unions, it encouraged the employees to have a direct communication with the company in the issues of concern (Star, 2015). This would make the issues to be taken seriously and follow up with the right actions. Due to the global recession, the retailer agreed to form unions for workers in China so that they would be allowed to carry out their operation in the country where they have ambitious expansion plans. China is the country where the operations of the company lag behind in the global rivalry. In one of the claims that were presented in the courts, the retailer has been considered to engage in unfair labor practices under a different section of the labor code.
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Hi I Need Help With Essay On Unit 5 Db Paper Must Be At Least 250 Words Please N
/in Uncategorized /by developerHi, I need help with essay on Unit 5 DB. Paper must be at least 250 words. Please, no plagiarized work!
Most of the gases occur naturally in the air while others are due to human activities. They include carbon dioxide, methane, and nitrous oxide.
Global warming is real. This is due to the release of greenhouse gases in the atmosphere that cause the earth temperature to rise. Of all the greenhouse gases emitted into the atmosphere, carbon dioxide occupies the large percentage of emission (Hogue, Johnson & Kemsley, 2013). This is mainly due to the burning of fossil fuels in electrical powered generation and industrial production. There is evidence that global warming is true and continues to take place. This is seen at the speed in which ocean level is rising. This is because global warming results to warming water that then increase water capacity. The increased water volume is also due to melting of glaciers. The melting of glaciers continues to be reported in Greenland and West Antarctica (Conservation International, 2012). Increased water volume has negative consequences for islands in the Caribbean and low-lying coastal areas
Sound science is a term used when defending an argument on an issue. This term is used to indicate that individuals in a case have facts on their side (Society of Environmental Toxicology and Chemistry, 1999). This term has helped in supporting the theory of global warming, as there is evidence that it is affecting people in different parts of the globe.
There are various ways to reduce carbon emission. They involve the use of nuclear energy as a source of electricity, reliance on geothermal and wind power, planting of trees, and reduction of fossil fuel
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Hi I Need Help With Essay On Unit 5 Seminar Capstone Paper Must Be At Least 250
/in Uncategorized /by developerHi, I need help with essay on Unit 5 seminar capstone. Paper must be at least 250 words. Please, no plagiarized work!
Validating her fillings will help her feel normal and affirm to her that any other person going through a similar event would feel like she does. The other step will be to offer therapy in order to help the client understand how abuse happens, signs of an abusive partner, and alternatives for dealing with abuse before she gets into a crisis. I will give the client information. Such information includes where she can report abuse cases, domestic violence helpline services, option of separating with her abusive partner until he receives intervention, or the alternative of terminating the abusive marriage relationship. I would then help her decide on what would work best for her. Finally, the client and I would explore alternatives of empowering her socially, culturally and economically (Kanel, 2007). Such alternatives include joining a local community support group, choosing the cultural practices and beliefs that do not discriminate or allow domestic violence and getting a job.
Finally, projecting into the future, the client will handle a similar situation with courage and conscientiousness. She will detect abuse before it happens and avert it timely. This way, she will not be in a crisis because she will break the cycle of domestic
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Hi I Need Help With Essay On Unit 7 Mini Paper Must Be At Least 500 Words Please
/in Uncategorized /by developerHi, I need help with essay on Unit 7 mini. Paper must be at least 500 words. Please, no plagiarized work!
It is important to note how long the carnival will last for a budget to be set. In this case it commences from the 11th to the 20th of September, 1998. A budget committee should be set for the selection process of any proposal. This helps in determining the amount of funds that will be allocated the carnival. Their work is to come up with a budget for every single detail that will be available. The budget proceedings also includes a charge incurred during the week of the carnival. In this case, the risk to be experienced will be overcharging the citizens since the people of Spokane County will take part in the selection of qualified firms for setting this event. The firm that submits an affordable and a well evaluated budget will stand a chance to secure the available carnival contract.
Quality of products is a crucial aspect of getting into a contract with Spokane County. Nobody will want poor quality products of their carnival, it poses a risk not only to the firm but also to all the people attending the carnival. An opportunity in the contract exists where quality services are offered and well trained workers are employed based on the level knowledge and skills (Jaafari, 2001). Services offered have to meet the eye of the consumer. The major risks likely to be encountered with this field will be failure to satisfy consumers’ needs. This may lead to a termination of the contract mainly because it is a long term contract for up to 5years.
The Spokane County Carnival is expected to have technical equipment such as carnival rides that are meant to satisfy the residents. The firm that provides these services and state of art equipment at reasonable fees lands the contract. According to Jaafari 2001, innovativeness is also crucial, people are accustomed to change, and hence the firm that comes up with new ideas, new carnival games, and shows have a
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Hi I Need Help With Essay On Urban Futures Field Trip Design And Conduct Mobilit
/in Uncategorized /by developerHi, I need help with essay on Urban futures: Field trip design and conduct (Mobility). Paper must be at least 500 words. Please, no plagiarized work!
Majority of these zones only allow emergency vehicles to access the areas (Melia, Barton & Parkhurst 2010). Delivery vehicles can access the areas at specific time or alternatively use side streets.
There are a number of plazas and arcades similar to the Times Square area in New York. The arcades comprise of boutiques and eateries (Scheurer 2001). As mentioned earlier, the real estate price in the area is high. This means that majority of the business owners are in the high-class status. This is similar to other Malls in other cities. The medium class and the lower class cannot be able to afford house prices in the area. Rundle Mall is a commerce hub in the area. This means there are no residential and industrial buildings in the area. Times Square also contains commercial houses with no industrial activity taking place within that area (Melia, Barton & Parkhurst 2010). The area also comprise of wide streets lined up with artifacts at strategic points. ‘The Spheres’ is one of the best known sculptures in the Australian mall. Times Square area in New York is also lined with a number of artifacts such as those in the Duffy area.
Rundle Mall and Pedestrian Mall areas in Adelaide were set aside as a result of a strategic plan. Experts and local interest groups came up with the idea. Currently, there is a master plan that is significantly set to transform Rundle Mall. The design phase of the master plan has already been completed. Malls in the United States were also established through a strategic plan.
Pedestrian Mall and Rundle Mall have a number of advantages in terms of mobility. Some of the areas are closed to traffic and hence pedestrians can be able walk without the hustle and bustle created by motorists. Development in the area is manned by a management authority that comprise of a Board of Directors (Schriever 2007). The authority is also responsible for ensuring that there is high security in the area. People
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Hi I Need Help With Essay On Using Comparison And Contrast Of Novel Book Verses
/in Uncategorized /by developerHi, I need help with essay on Using Comparison and Contrast of Novel/Book Verses Movie:. Paper must be at least 1750 words. Please, no plagiarized work!
Third, most movies will omit or add some content to the original material to make it suit the directors’ ideas. Finally and of crucial magnitude is a difference in interpretation. a director might misinterpret the original content thus confuse the audience. With this information in mind, the following text will evaluate Gary Ross’ film The Hunger Games whose screenplay is borrowed from Suzanne Collin’s Novel The Hunger Games and give supportive evidence of variations or similarities between the two.
The Hunger Games book is a sci-fi novel produced in 2008 by Suzanne Collins, an American writer, and it revolves around the life of a sixteen-year old girl named Katniss. It was to be later used as a screenplay in founding a movie in a similar title, and almost similar development. Katniss lives in the American north in a post-apocalyptic nation named Panem which is highly advanced, and upon its throne sits some mighty autocratic president. The title “hunger games” arises from an annual festival held in the state annually in which every district [there are several] in the nation produces a girl and a boy in their teenage years who are put to fight in a televised real life battle, only ending when a single contestant has eliminated all the contestants or rivals. Katniss was not chosen to represent District 12 at the hunger games but she took up the task in place of her younger sister who was to be the district 12’s representative for the approaching festival. It was the love for her sister that prompted her to take up the challenge in her sister’s place. Together with her male counterpart Peeta Mellark also from District 12, they take up the challenge which apart from seeing them form a coalition in fighting against the brutal system binds the two in a romantic relationship. The story ends when the contestants and citizens coalesce and fight against the autocratic system of rule, ending the brutal games and restoring normalcy
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Hi I Need Help With Essay On Using Forrester And Drexlers As A Guide What Should
/in Uncategorized /by developerHi, I need help with essay on Using Forrester and Drexlers as a guide, what should you do if you want to encourage team-based organization performance What risks would you face in doing this, and what would you therefore have to be careful of. Paper must be at least 1750 words. Please, no plagiarized work!
This is the reason why there are multiple consultants seeking to help organizations to overcome the challenges involved. Forrester and Drexler developed a model that can serve as an effective map for organizations opting for team-based organization performance. The two authors published an article, in which they described all the critical components of ensuring those teams function effectively. This paper will discuss the steps taken in an effort to encourage team-based organization performance. Moreover, the paper will highlight the potential risks for team-based organization performance approach, and highlight how to handle them effectively.
One of the critical steps in encouraging team-based organization performance is ensuring that there is a balance in the formation of the teams. An effective team is one, which comprises of the right individuals on the right team. This means that the composition of a team should depend on the specific tasks of the team. In accordance with Forrester and Drexler, composition of a team should also promote coherence.1 This means that individuals forming a team should be determined to take up their responsibilities and function as a whole. The organization should ensure that it offers supportive systems that create a favourable environment for the functionality of teams. Some of the setbacks that may result during the formation of a team are incongruence, team isolation, and the presence of organizational barriers. Unless the organization recognizes a realistic need for developing teams, then incongruence will occur because the team formation is for the wrong reasons. Therefore, the lack of coherence results to the isolation of the team. This occurs when a team does not experience belongingness to the entire organization.2 On the other hand, organizational barriers may involve issues such as inadequate resources for the team, and failure to recognize that teamwork is a collective activity and focusing
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Hi I Need Help With Essay On Using One Example Of A Cellular Oncogene Illustrate
/in Uncategorized /by developerHi, I need help with essay on Using one example of a cellular oncogene, illustrate molecular mechanisms of activation and the consequences for protein function; for this specific example, also provide information about the occurrence in cancer and any current treatments. Paper must be at least 500 words. Please, no plagiarized work!
The oncogene is also involved in the regulation of diverse behaviors of the cell as part of the larger Ras protein super-family. Their signaling activity results in the growth and division of cells, which means that over-activity on the oncogene’s part, will ultimately cause cancer (Hanahan & Weinberg 2011, p. 654). In fact, the Ras oncogene is the most common in cancer with over 20% of all human cancers possessing permanent Ras mutations and 90% in some cancers like pancreatic cancer. Therefore, inhibitors of the Ras oncogene have been studied in the search for cancer treatment.
Ras is a protein that binds guanosine nucleotides and is referred to as G-protein. As with other G-proteins, Ras functions as a binary signaling switch with binding of GTP switching it on, while binding of GDP acts to switch it off. The additional phosphate functional group ensures that the switch regions are configured as a loaded spring at Gly-60 and Thr-35 (Weinberg 2013, p. 115). Therefore, the cycling between inactive GDP and active GTP molecules controls the deactivation and activation of the Ras oncogene. Exchange between these molecules is, in turn, facilitated by GEF and GAP molecules, of which GEF promotes the release of GDP and attachment of GTP to the Ras oncogene. Examples of GEF’s include cdc25 and Son of Sevenless (Bock & Marsh 2010, p. 65).
The GEF protein catalyzes the release of GDP by inserting near the binding sites for Mg+ and the P-loop, thus inhibiting their interaction with P-. Within the P-loop, a lysine group is pulled away from GDP by negative residues, increasing the distance between switch I and guanine, and breaking the contact between GDP and Ras (Bock & Marsh 2010, p. 65). Since there is an abundance of activated GTP molecules in the cell, it predominantly binds to the Ras molecule’s nucleotide binding site. In this configuration, the oncogene has heightened
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