Hi, I need help with essay on Hemolytic Anemia in G6PD Patients. Paper must be at least 1000 words. Please, no plagiarized work!

As G6PD converts NADP to NADPH which prevents the oxidative damage to the cells but red blood cells depend solely on this pathway to prevent oxidative damage so R.B.Cs are the most commonly and most severely damaged population of cells due to the deficiency of this enzyme.

&nbsp.Mark A. Belsey (1973) explained that the G6PD deficiency has got a sex-linked inheritance. The phenotypic expression of the disease a great degree of variability and the reason being the presence of one euchromatic and one heterochromatic chromosome which is inactive is present in the female heterozygous individual. The pattern of X linked inheritance precludes the possibility that inactive X chromosome was either derived from paternal or the maternal side so the presence of mosaicism is essential in which paternal x in inactive in some cells and maternal X is inactive in others. Mark A. Belsey (1973)

&nbsp.The rigorousness of enzyme deficiency often does not associate well with the clinical severity of genetic diseases. Thus, some G6PD variants linked with rigorous enzyme deficiency, such as Union and Markham, cause no hemolytic problem, while some variants related with less severe deficiency, such as Manchester, Alhambra, and Tripler, cause chronic hemolytic anemia. The kinetic characteristics of these alternative enzymes have not explained the discrepancy. However, assessment of the normal and variant enzymes under pretended physiologic conditions, with the effects of various intermediate metabolites and co-enzymes in red cells being taken into consideration, reveal that the G6PDs from hemolytic variant subjects are strongly inhibited by a physiologic concentration of NADPH because of their high Michaelis constant for NADP or low inhibition constant for NADPH, and they are more sensitive to inhibition by ATP.

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Hi, I need help with essay on HIgh frequency oscilatory ventilation in adults. Paper must be at least 750 words. Please, no plagiarized work!

From that time individuals have learnt that as much as mechanical ventilation is always lifesaving also it can be injurious, particularly in patients who suffer from ARDS (acute respiratory distress syndrome). ARDS may also lead to refractory hypoxemia that can always trigger attempting ventilation strategies that are nonconventional like use of prone positioning, nitric oxide or recruitment maneuvers. HFOV (high frequency oscillatory ventilation) has emerged to be a rescue strategy for ARDS adults. To add to that, as it injures the lung is no more than ventilation conventional modes it can also be preferably suited to apply early in acute respiratory distress syndrome.

High frequency oscillatory ventilation fits in the range of high frequency modes of ventilation whose main concept is breaths delivery at low volumes of tides and high frequency modes of ventilation which are always beneath the anatomy dead space. The high frequency mode is generally divided into the ones in which expiratory stage is passive and the ones in which there is an active expiration. Examples of tools using passive expiration are positive pressure ventilation and jet ventilation of high frequency (Miller, pp.1446)

During HFOV high airway and very minute volumes pressure are used to prevent injuries form over distention and repetition reopening and collapse of the atelectrauma (lung). This allows for optimization of exchange of gas and possibly reduces iatrogenic damage. Oscillate trial is a varied Centre RCT where the mature individuals with severe ARDS were indiscriminately attached to HFOV or to convectional strategy: high pressures were used for both groups to keep lung recruitment at its maximum. The basic result was the in hospital death rate from any source.

The oscillatory was brought to a stop after five hundred and forty eight out of the planned one thousand two hundred patients had passed through randomization as the application of HFOV

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Hi, I need help with essay on Hip and Knee Issues. Paper must be at least 1000 words. Please, no plagiarized work!

With such a reputation, this hospital would likely play host to various cases of knee and hip injuries and such cases would most likely involve older adults. It is therefore important to maintain the expertise of this hospital in the knee and hip injuries in order to ensure adequate services for older adults and to ensure their recovery and return to daily activities after knee and hip surgeries. Learning in the nursing program From the nursing program, I have learned various health teachings in order to prevent falls among the elderly and in order to help the elderly individuals regain mobility after knee and hip injuries. I have learned in the course of the nursing program that due to the wear and tear of the aging process, older adults have brittle bones. With their brittle bones, falls and injuries can often cause fractures (to their hips or their arms). These injuries can often lead to limited mobility and can further deteriorate the quality of their lives. It is therefore important to prevent falls among elderly patients and to ensure an effective rehabilitation process. While being involved with the agency, it is important for me to incorporate the things I have learned in the nursing program to my patients in the hospital. Elderly patients recovering from knee and hip injuries need to be taught about the rehabilitation process they have to undergo after their surgery, how they can slowly regain their mobility, and how they can eventually conduct their daily activities.

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Hi, I need help with essay on Historical Role Of Slavery. Paper must be at least 500 words. Please, no plagiarized work!

Swift in Gulliver’s Travel describes the human nature in a satirical form. He shows how honesty and on the other hand lying are incorporated into the human nature and how well they fit. Swift does this by taking Gulliver through a self-deception journey and getting to a point of experiencing e depicted authenticity that is straightforward. Swift, therefore, reveals human nature as being faced with issues of telling the truth, lying, hypocrisy and authenticity and reality and illusion (Jan 16). Human nature in Voltaire’s Candide emerges as being ridiculous and depicts that whatever happens is for the best of all the possible worlds. He focuses on the capacity of the human to reason and believes that the only time that humanity can reform is when an individual is able to think by themselves and independent of what others think (Jefferson 146). Voltaire sees the possibility of challenges that face individuals with regard to belief before they can realize that optimism does not provide a realistic basis to enable them to perceive the world. He clearly shows that people must think independently in order to achieve all that they ate capable of achieving (Lowers 44). Shelly in Frankenstein brings out the human nature as being to judge from appearance. The people just see the external features of the creature and from this labels him the monster (Allen 93).They do not see beyond his external deformities even to realize the good aspects that he possesses such as being an eloquent speaker.&nbsp.

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Hi, I need help with essay on History J3. Paper must be at least 500 words. Please, no plagiarized work!

uiano gives a vivid description of the Middle Passage which demonstrates the terror of the prisoners, the abject conditions on board and the attitude of the slavers to their cargo.

The captured African slaves are absolutely terrified on their passage. The main reason for this fear is the ignorance of the Africans, as this is their first encounter with Europeans. Equiano’s horror is “heightened by my ignorance of what I was to undergo” (Equiano, 1789).The fair complexion, long hair and alien language of the white men makes Equiano believe that they are “bad spirits, and that they were going to kill me” (Equiano, 1789). The large copper furnace and the dejected, fettered prisoners reinforce his fear of being sacrificed. Another factor which contributes to Equiano’s fear is the water: “not being used to the water, I naturally feared that element the first time I saw it” (Equiano, 1789). Most of the captured slaves are from interior Africa and have never seen the sea. The ship and its navigation seem magical to the Africans.

The conditions on board the slave ship are extremely miserable. The slaves are confined to the unventilated hold, where they are chained and packed tightly together. The initial cargo of slaves is supplemented by the additional slaves taken on at sea. This makes the hold “so crowded that each had scarcely room to turn himself” (Equiano, 1789). Equiano paints “a scene of horror almost inconceivable”: the heat, the toxic miasma of perspiration, the suffocating atmosphere, the increasing irritation of the chains, the groans of the dying, the shrieks of the women, the stench of humanity and the tubs of human excreta “into which the children often fell, and were almost suffocated” &nbsp.(Equiano, 1789). The stink of the holds is beyond tolerance.The pestilential air makes the slaves ill and even causes fatalities. The rations are insufficient to satisfy the slaves’ appetite. It is a mark of the slavers’ spite that they

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