Respond using one or more of the following approaches:
Ask a probing question, substantiated with additional background information, and evidence.
Share an insight from having read your colleagues’ postings, synthesizing the information to provide new perspectives.
Statistical Methods in Qualitative Research
Statistical Method
What is measured by this method
Circumstances for Use
Examples of use in Research Studies
Qualitative Content Analysis
Analyzes narrative data, and in-depth interviews. Can evaluate large volumes of data with intent to identify recurring themes and patterns. Attempts to break down elements of data into clusters. May be concurrent or sequential (Polit &Beck, 2017).
Good method for evaluating personal histories, perspectives, experiences. Best method for studying personal, sensitive situations (Sauro, 2015).
Examples of this methodology include evaluation of the experience of a rape victim, what it feels like to have an abortion, how it feels to have lived through a disaster.
Ethnographic analysis
Evaluates cultural phenomena, patterns, perspectives. Requires “participant observer” technique. No preconceived hypothesis. May take months or years to complete. Maps and flowcharts are tools to help illustrate findings (Polit & Beck, 2017).
Method to “acquire a deep understanding of the culture being studied” (Polit & Beck, 2017 p. 538).
An example of ethnographic analysis could include a research study with ethnographers integrating with Native Americans living on a reservation while observing everyday life seeking to extrapolate overlying cultural issues.
Phenomenologic Analysis
Attempts to understand the essence of experiencing a particular phenomenon by observation, interviews, and outside research. Descriptive analysis
Method for understanding individual perspectives of experiencing a certain phenomenon. Seeks to extrapolate commonalities and themes among subjects (Sauro, 2015).
Conducting interviews with persons who have experienced hallucinations, with the intent to understand their perspective and experience of the phenomenon, is an example of this method of research.
Grounded Theory Analysis
Aim is to provide theories and explanations for phenomena based on previously coded information Uses interviews and previous accepted research. Unlike Qualitative content analysis, which seeks to break down information, Grounded theory strives to put information back together (Polit & Beck, 2017).
Method for development of theories, Could be used meta-analyses or systematic reviews.
An example of a grounded theory analysis is” Beck’s (2002) model of mothering twins” as cited in Polit & Beck (2017).
Focus Group Analysis
Analyzes group data in relation to a specific topic. Group interviews, recordings, and field notes .are instruments for conducting this type of research.
May be used for evaluation of a potential survey tool, consensus on a new product. Researchers seek to extrapolate recurring themes.
An example of a focus group analysis might be to evaluate perceptions of a new product being marketed to test for general consensus of its desirability.
Quasi-statistics: a tabulation of the frequency with which certain themes or insights are supported by the data
Qualitative content analysis: analysis of the content of narrative data to identify prominent themes and patterns among the themes
Domain analysis: 1st of 4 levels of data analysis, domains are units of cultural knowledge, are broad categories that encompass smaller ones. Ethnographers identify rational patterns among terms in the domains are used by members of the culture. Ethnographer focuses on the cultural meaning of terms and symbols used in a culture
Taxonomic analysis: second level of data analysis, ethnographers decides how many domains the analysis will encompass. Taxonomy is then developed to illustrate the internal organization of a domain and the relationship among the subcategories of the domain
Taxonomy: a system of classifying and organizing terms
Componential analysis: relationships among terms in the domains are examined; ethnographer analyzes data for similarities and differences among cultural terms in a domain.
Theme analysis: cultural themes are uncovered; domains are connected in cultural themes, which help to provide a holistic view of the culture being studied. The discovery of cultural meaning is the outcome.
Holistic approach: researchers view the text as a whole and try to capture is meanings
Selective approach: researchers highlight or pull out statements or phrases that seem essential to the experience under study
Detailed approach: researchers analyze every sentence
Hermeneutic circle: signifies a methodological process in which to reach understanding, there is continual movement between the parts and the whole of the text being analyzed
Exemplars: illuminate aspects of a paradigm case or theme
Substantive codes: substance of the topic under study is conceptualized through substantive codes. Substantive codes are either open or selective
Open coding: used in the first stage of the constant comparative analysis,
captures what is going on in the data. May be actual words stated by participant. In open coding,
data are broken down into incidents and their similarities and differences are examined. Raw
data interpreted
Three Levels of Open Coding: Levels I, II, III
Level I codes: in vivo codes, derived directly from the language of the
substantive area and have vivid imagery
Level II codes: Researchers constantly compare new level one codes to
previously identified ones and then condense them into broader level II
codes
Level III codes: theoretical constructs, most abstract, add scope beyond local
meanings
Core category: pattern of behavior that is relevant and/or problematic for participants
Selective coding: can have 3 levels of abstraction, researchers code only those data that are related to the core variable
Basic social process (BSP): evolves over time in two or more phases, all BSP’s are core variables, but not all core variables have to be BSPs
Emergent fit: prevents individual substantive theories from being “respected little islands of knowledge”
Axial coding: analyst codes for context
Paradigm: used as an analytical strategy to help integrate structure and process
Central category: core category, which is the main theme of the research
Initial coding: pieces of data (words, lines, segments, incidents) are studied so the researcher begins to learn what the participants view as problematic
Focused coding: the analysis is directed toward using the most significant codes from the initial coding
Congruent methodological approach: analyzes interaction data in the same manner as a group or individual data
Sociograms: can be used to understand the flow of conversation as it goes around the members of the focus group
Incubation: process of living the data, a process in which researchers must try to understand their meanings, find their essential patterns, and draw legitimate, insightful conclusions
Conceptual files: physical files in which coded excerpts of data relevant to specific categories are placed
Themes: involves the discovery nor only of commonalities across participants but also of natural variation and patterns in the data
Metaphors: figurative comparisons used to evoke a visual or symbolic analogy
Quasi-statistics: involves a tabulation of the frequency with which certain themes or relations are supported by the data
Qualitative content analysis: can vary in terms of an emphasis on manifest content or latent content and in the role of induction
Managing Qualitative Data
Computer-assisted qualitative data analysis software (CAQDAS): a program that can take uploaded data files, code the narratives, retrieve information, and display text for analysis
![Text Box: • Text retrievers-locate text and terms in a database. • Code-and-retrieve packages allow researchers to code text. • Theory building software functions to examine relationships between concepts, develop hierarchies of codes, diagram, and create hyperlinks to create nonhierarchical networks. • Concept mapping constructs sophisticated diagrams. • Data conversion/collection software converts audio into text.]()
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Within a qualitative data analysis there is not statistical tests, because qualitative research is based on thoughts, open ended questions, interpretations and interviews not numerical values. Data within qualitative research is understood and analyzed during the entirety of the process. “Researchers interpret the data as they read and reread them, categorize and code them, inductively develop a thematic analysis, and integrate the themes into a unified whole,” (Polit & Beck, 2017, p.549). There is not a step by step understanding of how the process occurs of interpreting the data, researchers “live” within the data by understanding the meanings, looking for patterns, draw valid, discerning conclusions. An additional importance of understanding of the facts is having the inventiveness to find the “aha” meaning of the information and discovery of the meanings of the facts gained (Polit & Beck, 2017).
The importance of the interpretation is just as important as the validity of the data. Thorough and sensible researchers have a high standard of their data interpretation by dissecting themselves, peers and outside reviewers. It is vital that the qualitative researchers consider possible different explanations or meanings other than their own (Polit & Beck, 2017).
It is important nurses to understand statistical data because this is a large part of the work nurses base the practice on is evidence based, which means understanding the research behind the reason of the practice is important to understand. According to Hayat, it is important to understand the difference between statistical significance and clinical importance, researchers tend to use statistics to claim proof and scientific breakthrough. Significance testing can be used to decide which data may be considered evidence to support a practice change (2010). “Judgment and subjectivity are necessary and part of the decision-making process. Statistical significance is not a measure of importance; it is a subjective and qualitative construct. Researchers conducting quantitative analyses should quantify the magnitude of an effect. The value of the data collected should be assessed by examining study design, bias, and confounding variables, as well as meaningfulness of the results to the topic under study,” (Hayat, 2010, p.222). Nurses must consider this and have an understanding when utilizing statistical methods to base their practice changes.
References
Hayat, M. J. (2010). Understanding Statistical Significance. Nursing Research, 59(3), 219–223
Polit, D.E. & Beck, C.T. (2017). Nursing Research: Generating and Assessing Evidence for Nursing
Practice 10th ed. Philadelphia, PA: Wolters Kluwer
Sauro, J., (2015. October 13). Five types of qualitative methods, Retrieved from https://flic.kr/p/4PXXCYp.
By: Casey Hoffman, Tami Frazier, Sarah Pudenz, and Elizabeth Wilson
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Positive Response To This Post 150 Words Due October 18 At 1000 Am Est
/in Uncategorized /by developerSuicide is the taking of own life which is a “tragic reaction to stressful life situations (Suicide and suicidal thoughts, 2015).” The national institute of health reported ages 10-24 year olds in 2014 was the second leading cause of death with a total count of 5,504 deaths in the US (Advancing research to prevent youth,n.d.). Erickson’s stages of development for the adolescent shows the teen must successfully concur the two stages of development – identity vs. identity confusion and intimacy vs isolation (Miller, 2017). Teens who are struggling with the first and second stage will become socially isolated (Miller,2017). Erikson’s theory predicts “when adolescents are unable to successfully answer the questions of identity during this stage of development, they may experience feelings of inadequacy and despair, which can eventually lead to depression (Miller,2017). Depression left untreated can lead to suicide.
Health professionals can utilize primary, secondary, and tertiary methods to help with health prevention of suicide. “ Primary suicide prevention aims to reduce the number of new cases of suicide in the general population. Secondary prevention aims to decrease the likelihood of a suicide attempt in high-risk patients and Tertiary suicide prevention occurs in response to completed suicides and attempts to diminish suicide contagion (Ganz, n.d.).”
In general, if a true emergency is occurring 9-1-1 should always be the first line to call for help. When teens are struggling through thoughts of despair and potential suicide the communities do have resources to reach out to. As followed are some of the resources: Transitional Age youth support- Mental health services: (360)918-7860; Crisis Line: (360)586-2800; National Suicide Prevention Lifeline: (800)273-Talk (community youth services, n.d.).
As the nurse it is our duty to obtain a precise assessment of the teen through thorough questions and observations. The nurse should be mindful of some risk factors which place this age group at higher risk are as followed: a previous suicide attempt, mental disorders- schizophrenia/social anxiety, substance abuse, abused or mistreated, history found in family, hopelessness, lack of social support, access to means or methods for suicide (Preventing Teen Suicide, n.d.). A main nursing intervention in assisting a suspected depressed teen is to show active listening and presence.
Advancing Research to Prevent Youth Suicide. (n.d.). Retrieved October 17, 2017, from https://prevention.nih.gov/programs-events/pathways-to-prevention/workshops/suicide-prevention
Ganz, D., Braquehais, M. D., & Sher, L. (n.d.). Secondary Prevention of Suicide. Retrieved October 17, 2017, from http://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1000271
(n.d.). Retrieved October 17, 2017, from http://www.communityyouthservices.org/p_suicide_prevention.shtml
Miller, R. (2017, June 13). Erik Erikson’s Theory About Adolescent Depression. Retrieved October 17, 2017, from https://www.livestrong.com/article/560899-erik-eriksons-theory-about-adolescent-depression
Preventing Teen Suicide. (n.d.). Retrieved October 17, 2017, from https://teens.webmd.com/preventing-teen-suicide#1
Suicide and suicidal thoughts: Take action to prevent a tragedy. (2015, August 28). Retrieved October 17, 2017, from http://www.mayoclinic.org/diseases-conditions/suicide/basics/definition/con-20033954
health 3 quest 1
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Post 1 Logan
/in Uncategorized /by developerI need a positive argument based in this discussion question. Respond to this argument in one or more of the following ways:
Ask a probing question, substantiated with additional background information, evidence or research.
Share an insight from having read your colleagues’ postings, synthesizing the information to provide new perspectives.
Offer and support an alternative perspective using readings from the classroom or from your own research in the Walden Library.
Validate an idea with your own experience and additional research.
Make a suggestion based on additional evidence drawn from readings or after synthesizing multiple postings.
Expand on your colleagues’ postings by providing additional insights or contrasting perspectives based on readings and evidence.
Use references
Mission, Vision, and Personal Goals
I have been a nurse for five years and spent a great deal of time thinking about my future role in nursing. I debated the pros and cons from the available list of master’s degree specialty tracks in nursing. At first, I thought that I might do nursing leadership as I enjoy leadership, but I changed my mind after realizing that I could lead change in any master’s degree role. I am passionate about psychiatry and decided on the psychiatric mental health nurse practitioner specialty track.
Over the course of a few months, I researched different universities and was drawn to Walden University. I liked that they offered a master’s degree in my specialty track as many universities have moved to the doctorate level. Also, I noticed that Walden had all the required accreditations that I was looking for in a university. After reading the Walden School of Nursing (SON) mission and vision statement, I realized that we have commonalities. According to the Walden University SON (2012), their mission is to thoroughly prepare graduates to transform society. The mission statement speaks to me as I would like to transform individuals and the community by providing high quality, cost effective, and relevant care.
Also, the Walden University program outcomes state that graduates will “apply their learning to specific problems and challenges in their workplace and professional settings” (Walden University, 2011, para. 5). This statement aligns with my objectives. I would like to earn more than a degree; I would like to apply knowledge gained, synthesize new practices, and implement it into nursing practice.
Incorporation of Social Change
Positive social change is a process for improving the daily lives of individuals, communities, and society. According to Walden University (2011), positive social change results in an enhancement of human and social conditions. I concur with this position and I would like to do the same in my community. I have taken my nursing practice as far as I can with my current education and scope. My plan for positive social change in my future practice is to look at an individual holistically to figure out how I can address social conditions preventing effective treatment. For example, “stable housing has been linked to recovery from addictions” (Knickman & Kovner, 2015, p. 165). This statement validates an existing hypothesis synthesized in my daily nursing practice. A lack of housing for chemically dependent individuals results in frequent inpatient readmissions. Positive social change will occur if the above-mentioned social condition can be addressed.
References
Knickman, J. R., & Kovner, A. R. (2015). Health Care Delivery in the United States (11th ed.). New York, NY: Springer Publishing.
Walden University. (2011). Student publications: Vision, mission, and goals. Retrieved from http://catalog.waldenu.edu
Walden University College of Health Sciences. (2012). About the school. Retrieved from http://www.waldenu.edu/colleges-schools/school-of-nursing/about
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Post 19210341
/in Uncategorized /by developerRespond using one or more of the following approaches:
Ask a probing question, substantiated with additional background information, and evidence.
Share an insight from having read your colleagues’ postings, synthesizing the information to provide new perspectives.
Statistical Methods in Qualitative Research
Statistical Method
What is measured by this method
Circumstances for Use
Examples of use in Research Studies
Qualitative Content Analysis
Analyzes narrative data, and in-depth interviews. Can evaluate large volumes of data with intent to identify recurring themes and patterns. Attempts to break down elements of data into clusters. May be concurrent or sequential (Polit &Beck, 2017).
Good method for evaluating personal histories, perspectives, experiences. Best method for studying personal, sensitive situations (Sauro, 2015).
Examples of this methodology include evaluation of the experience of a rape victim, what it feels like to have an abortion, how it feels to have lived through a disaster.
Ethnographic analysis
Evaluates cultural phenomena, patterns, perspectives. Requires “participant observer” technique. No preconceived hypothesis. May take months or years to complete. Maps and flowcharts are tools to help illustrate findings (Polit & Beck, 2017).
Method to “acquire a deep understanding of the culture being studied” (Polit & Beck, 2017 p. 538).
An example of ethnographic analysis could include a research study with ethnographers integrating with Native Americans living on a reservation while observing everyday life seeking to extrapolate overlying cultural issues.
Phenomenologic Analysis
Attempts to understand the essence of experiencing a particular phenomenon by observation, interviews, and outside research. Descriptive analysis
Method for understanding individual perspectives of experiencing a certain phenomenon. Seeks to extrapolate commonalities and themes among subjects (Sauro, 2015).
Conducting interviews with persons who have experienced hallucinations, with the intent to understand their perspective and experience of the phenomenon, is an example of this method of research.
Grounded Theory Analysis
Aim is to provide theories and explanations for phenomena based on previously coded information Uses interviews and previous accepted research. Unlike Qualitative content analysis, which seeks to break down information, Grounded theory strives to put information back together (Polit & Beck, 2017).
Method for development of theories, Could be used meta-analyses or systematic reviews.
An example of a grounded theory analysis is” Beck’s (2002) model of mothering twins” as cited in Polit & Beck (2017).
Focus Group Analysis
Analyzes group data in relation to a specific topic. Group interviews, recordings, and field notes .are instruments for conducting this type of research.
May be used for evaluation of a potential survey tool, consensus on a new product. Researchers seek to extrapolate recurring themes.
An example of a focus group analysis might be to evaluate perceptions of a new product being marketed to test for general consensus of its desirability.
Quasi-statistics: a tabulation of the frequency with which certain themes or insights are supported by the data
Qualitative content analysis: analysis of the content of narrative data to identify prominent themes and patterns among the themes
Domain analysis: 1st of 4 levels of data analysis, domains are units of cultural knowledge, are broad categories that encompass smaller ones. Ethnographers identify rational patterns among terms in the domains are used by members of the culture. Ethnographer focuses on the cultural meaning of terms and symbols used in a culture
Taxonomic analysis: second level of data analysis, ethnographers decides how many domains the analysis will encompass. Taxonomy is then developed to illustrate the internal organization of a domain and the relationship among the subcategories of the domain
Taxonomy: a system of classifying and organizing terms
Componential analysis: relationships among terms in the domains are examined; ethnographer analyzes data for similarities and differences among cultural terms in a domain.
Theme analysis: cultural themes are uncovered; domains are connected in cultural themes, which help to provide a holistic view of the culture being studied. The discovery of cultural meaning is the outcome.
Holistic approach: researchers view the text as a whole and try to capture is meanings
Selective approach: researchers highlight or pull out statements or phrases that seem essential to the experience under study
Detailed approach: researchers analyze every sentence
Hermeneutic circle: signifies a methodological process in which to reach understanding, there is continual movement between the parts and the whole of the text being analyzed
Exemplars: illuminate aspects of a paradigm case or theme
Substantive codes: substance of the topic under study is conceptualized through substantive codes. Substantive codes are either open or selective
Open coding: used in the first stage of the constant comparative analysis,
captures what is going on in the data. May be actual words stated by participant. In open coding,
data are broken down into incidents and their similarities and differences are examined. Raw
data interpreted
Three Levels of Open Coding: Levels I, II, III
Level I codes: in vivo codes, derived directly from the language of the
substantive area and have vivid imagery
Level II codes: Researchers constantly compare new level one codes to
previously identified ones and then condense them into broader level II
codes
Level III codes: theoretical constructs, most abstract, add scope beyond local
meanings
Core category: pattern of behavior that is relevant and/or problematic for participants
Selective coding: can have 3 levels of abstraction, researchers code only those data that are related to the core variable
Basic social process (BSP): evolves over time in two or more phases, all BSP’s are core variables, but not all core variables have to be BSPs
Emergent fit: prevents individual substantive theories from being “respected little islands of knowledge”
Axial coding: analyst codes for context
Paradigm: used as an analytical strategy to help integrate structure and process
Central category: core category, which is the main theme of the research
Initial coding: pieces of data (words, lines, segments, incidents) are studied so the researcher begins to learn what the participants view as problematic
Focused coding: the analysis is directed toward using the most significant codes from the initial coding
Congruent methodological approach: analyzes interaction data in the same manner as a group or individual data
Sociograms: can be used to understand the flow of conversation as it goes around the members of the focus group
Incubation: process of living the data, a process in which researchers must try to understand their meanings, find their essential patterns, and draw legitimate, insightful conclusions
Conceptual files: physical files in which coded excerpts of data relevant to specific categories are placed
Themes: involves the discovery nor only of commonalities across participants but also of natural variation and patterns in the data
Metaphors: figurative comparisons used to evoke a visual or symbolic analogy
Quasi-statistics: involves a tabulation of the frequency with which certain themes or relations are supported by the data
Qualitative content analysis: can vary in terms of an emphasis on manifest content or latent content and in the role of induction
Managing Qualitative Data
Computer-assisted qualitative data analysis software (CAQDAS): a program that can take uploaded data files, code the narratives, retrieve information, and display text for analysis
Within a qualitative data analysis there is not statistical tests, because qualitative research is based on thoughts, open ended questions, interpretations and interviews not numerical values. Data within qualitative research is understood and analyzed during the entirety of the process. “Researchers interpret the data as they read and reread them, categorize and code them, inductively develop a thematic analysis, and integrate the themes into a unified whole,” (Polit & Beck, 2017, p.549). There is not a step by step understanding of how the process occurs of interpreting the data, researchers “live” within the data by understanding the meanings, looking for patterns, draw valid, discerning conclusions. An additional importance of understanding of the facts is having the inventiveness to find the “aha” meaning of the information and discovery of the meanings of the facts gained (Polit & Beck, 2017).
The importance of the interpretation is just as important as the validity of the data. Thorough and sensible researchers have a high standard of their data interpretation by dissecting themselves, peers and outside reviewers. It is vital that the qualitative researchers consider possible different explanations or meanings other than their own (Polit & Beck, 2017).
It is important nurses to understand statistical data because this is a large part of the work nurses base the practice on is evidence based, which means understanding the research behind the reason of the practice is important to understand. According to Hayat, it is important to understand the difference between statistical significance and clinical importance, researchers tend to use statistics to claim proof and scientific breakthrough. Significance testing can be used to decide which data may be considered evidence to support a practice change (2010). “Judgment and subjectivity are necessary and part of the decision-making process. Statistical significance is not a measure of importance; it is a subjective and qualitative construct. Researchers conducting quantitative analyses should quantify the magnitude of an effect. The value of the data collected should be assessed by examining study design, bias, and confounding variables, as well as meaningfulness of the results to the topic under study,” (Hayat, 2010, p.222). Nurses must consider this and have an understanding when utilizing statistical methods to base their practice changes.
References
Hayat, M. J. (2010). Understanding Statistical Significance. Nursing Research, 59(3), 219–223
Polit, D.E. & Beck, C.T. (2017). Nursing Research: Generating and Assessing Evidence for Nursing
Practice 10th ed. Philadelphia, PA: Wolters Kluwer
Sauro, J., (2015. October 13). Five types of qualitative methods, Retrieved from https://flic.kr/p/4PXXCYp.
By: Casey Hoffman, Tami Frazier, Sarah Pudenz, and Elizabeth Wilson
"Looking for a Similar Assignment? Get Expert Help at an Amazing Discount!"
Post 19445059
/in Uncategorized /by developerRespond to two colleagues in one of the following ways:
If your colleagues’ posts influenced your understanding of these concepts, be sure to share how and why. Include additional insights you gained.
If you think your colleagues might have misunderstood these concepts, offer your alternative perspective and be sure to provide an explanation for them. Include resources to support your perspective.
Main Post
Agonist-to-Antagonist Spectrum
The agonist-to-antagonist spectrum of action refers to the action that is taken by a neurotransmitter to produces a conformational change (Stahl, 2013). The spectrum starts with the agonist action, which, with the help of a second-messenger, can turn on the full potential of change (Stahl, 2013). Full agonists can be natural transmitters used to produce change. An antagonist blocks the conformational change of the potential of the transmitter for binding with the intended agonist (Stahl, 2013). The role of the antagonist is to keep the receptors in a baseline state in order to reverse what the agonist has done (Stahl, 2013). This is the opposite end of the spectrum and seeks to block agonists. In the middle, some partial agonists mimic its agonist partner to a lesser degree, and inverse agonists stop all activity from occurring on the receptor (Stahl, 2013). The conformational change is needed for a receptor to open to the action of drugs, particularly, psychopharmaceutical medications in this case.
G couple proteins and Ion gated channels
G couple proteins are used at the binding site of a neurotransmitter to act as a conduit for enzymes (Stahl, 2013). Whereas, ion gated channels exist as targets to regulate chemical neurotransmitters (Stahl, 2013). Ion gated channels consist of channels and receptors that can only be opened by the neurotransmitters. Conversely, G couple proteins attach to neurotransmitters and conform to enzymes to serve as a channel for a second messenger (Stahl, 2013). Most psychotropic medications aim for the ion gated channels, which open through chemical neurotransmission and initiate the signal transduction cascade (Stahl, 2013). The cascade results in faster uptake of psychotropic medications into the system.
The Role of Epigenetics
According to DeSocio (2016), epigenetics is the study of how genomes that undergo changes with certain molecular compounds and environmental changes can leave the essential DNA unchanged. It is a modification of gene expression that is independent of the DNA (DeSocio, 2016). DNA is the code that determines much of who we are. Changes in that code can be seen as a result of heredity, the environment, or neurotransmission (Stahl, 2013). These alterations affect individuals at a physical, emotional, and psychological level. Stress and adversity play a significant role in epigenetics by changing the genomes, which in turn leads to changes in a person’s DNA (Park et al., 2019). These alterations influence psychological issues related to many individuals. It is essential to know how to combat these changes when determining a plan of care for clients.
Implications of Findings to Prescribing
As nurse practitioners, it is essential to have an extensive understanding of how the above processes affect the way we prescribe medications to clients. It is also essential to take into consideration how the environment impacts maintaining optimal health and healing (DeSocio, 2016). Knowing the mechanisms of action for medications that we are prescribing is vital to providing competent care. For example, a patient with a generalized anxiety disorder (GAD) is prescribed Venlafaxine. The PMHNP needs to understand that the Venlafaxine works by boosting the serotonin, norepinephrine, and dopamine neurotransmitters (Stahl, 2014). This action blocks serotonin reuptake, norepinephrine reuptake, and the dopamine reuptake (Stahl, 2014). Each of these actions then increases these neurotransmissions in the brain providing therapeutic results.
References
DeSocio, J.E. (2016). Epigenetics: An emerging framework for advanced practice psychiatric nursing. Perspectives in Psychiatric Care, 52(3), 201-207. https://doi.org/10.1111/ppc.12118
Park, C., Rosenblat, J.D., Brietzke, E., Pan, Z., Lee, Y., Cao, B., Zuckerman, H., Kalantarova, A., McIntyre, R.S. (2019). Stress, epigenetics, and depression: A systematic review. Neuroscience and Biobehavioral Reviews, 102, 139-152. https://doi.org/10.1016/j.neubiorev.2019.04.010
Stahl, S.M. (2014). The prescriber’s guide (5th ed.). New York, NY: Cambridge University Press.
Stahl, S.M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications. (4th ed.). New York, NY: Cambridge University Press.
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Post 19477263
/in Uncategorized /by developerRespond of your colleagues who were assigned to a different case than you. Explain how you might apply knowledge gained from your colleagues’ case studies to you own practice in clinical settings.
Main Post
Sleep/Wake Disorders
The patient is an obese 70-year-old female with a chief complaint of “being sad.” Her husband passed away several years ago due to coronary artery disease (CAD). She lives at home alone and has a home health aide help her. Her son comes to visit her often. She was feeling well until her hearing began to diminish in both ears. Her mobility has declined, so she has not been able to get out as much. She is often lonely at home. She has daily crying spells, is often very tired, has good insight to her illness, and wants to get better.
Three Questions to Ask the Patient and Why
The case study mentioned that the patient is a candidate for cochlear implants, but it is a long way off. Thus, my first question to ask the patient is what is preventing her from getting cochlear implants?
She began experiencing sadness when she began to lose her hearing and mobility. Therefore, regaining her hearing may help decrease the depression. If its financial reasons, maybe there are resources that can help her. Finding out the reason the patient isn’t getting the implants can help the provider and patient find solutions.
The patient also mentioned that her sleep was “awful”, stating her legs “ache and jump”, she takes frequent naps during the day, and admits to snoring frequently. Thus, the second question I would ask is what are her sleeping habits like?
Individuals who have good sleep habits sleep better. Getting better sleep can be obtained by being consistent by going to bed at the same time each night and waking up the same time each day (Centers for Disease Control and Prevention, [CDC], 2016). Individuals can make sure the room is dark, quiet, and cool (CDC, 2016). Additionally, remove electronic devices, avoid large meals, caffeine, and alcohol can help with getting better sleep (CDC, 2016). My third question would be what do you do when you are sad? Individuals who are depressed often have a negative view of the world and often think of themselves as worthless (This Way Up, n.d.). They often blame themselves when something bad happens and feel like they are unlucky (This Way Up, n.d.). Thus, helping individuals identify negative thinking and reframe the way they think about life can help improve depressive symptoms (This Way Up, n.d.).
People to Speak to with Specific Questions to Ask
The first person I would want to speak to is the patient’s son. The case study states the son visits her often so he should know the patient’s habits. First, I would ask him the same questions I asked the patient such as what is preventing the patient from getting cochlear implants, what are her sleep habits, and what does she do when she is sad? By asking the son the same questions, insight can be shown on how the son views things and how the patient views things. I would also him when he began to notice her depressive symptoms because that will help provide a timeline as to when it all began.
The second person I would talk to is her home health aide because she is familiar with the patient. I would ask her what the patient’s home life is like such as how is she maintaining her house? Is she able to clean up after herself? How is she doing with activities of daily living?
These questions can provide insight on the severity of the patient’s depressive symptoms.
Physical Exams and Diagnostic Tests and How Results Would Be Used
The first diagnostic test I would want to perform on the patient is the 9-item Patient Health Questionnaire (PHQ-9). The PHQ-9 is a screening tool for major depression (Na et al., 2018). The test is a reliable and valid measurement of depressive symptoms that also asks about the individual’s thoughts of death or self-injury within the last two weeks (Na et al., 2018). The results would be used to determine the severity of her depression. Another diagnostic test that can be performed on this patient is a polysomnography. A polysomnography is a sleep study that helps providers diagnose sleep apnea, periodic limb movement disorder, restless leg syndrome (RLS), insomnia, and nighttime behaviors (National Sleep Foundation, n.d.). The results would be used to can help determine the cause of her daytime sleepiness such as sleep apnea or RLS. I would also want to run a complete blood count (CBC) with differential on the patient. I would specifically want to obtain a red blood cell count (RBC) and white blood cell count (WBC). Thus, a CBC with differential would help determine if the patient is fatigued due to anemia or an underlying infection.
Three Differential Diagnosis and Why
The three potential differential diagnoses include:Major Depressive DisorderPersistent Insomnia Disorder Obstructive Sleep Apnea Hypopnea The most likely differential diagnosis is major depressive disorder (MDD). The diagnostic criteria for MDD is five or more symptoms during the same 2-week period and a change from previous functioning (American Psychiatric Association, 2013). The symptoms include: depressed mood most of the day, marked diminished interest or pleasure in all or almost all activities most of the day, significant weight loss or weight gain, insomnia or hypersomnia neatly every day, psychomotor agitation or retardation nearly every day, fatigue or loss of energy nearly every day, feelings of worthlessness or excessive or inappropriate guilt nearly every day, diminished ability to concentrate, and recurrent thoughts of death (American Psychiatric Association, 2013). The patient fits this diagnosis as evidence by depressed mood, diminished interest in activities she used to enjoy, fatigue, diminished ability to concentrate, and psychomotor retardation.
Two Pharmacological Agents and Dosing and Why
One pharmacologic agent that can be tried is doxepin 3 mg at bedtime for insomnia. Doxepin works by boosting serotonin and norepinephrine by blocking the serotonin reuptake pump and norepinephrine reuptake pump (Stahl, 2017). At hypnotic doses, doxepin blocks histamine-1 receptors, which promotes sleep (Stahl, 2017). Doxepin is a substrate for CYP450 2D6 and has a half-life of 8-24 hours (Stahl, 2017). In the elderly, the recommended dose for insomnia is 3 mg per day (Stahl, 2017). Another pharmacologic agent that I would like to start the patient on is bupropion (extended release) XL 150 mg daily in the morning. Bupropion is used to treat MDD and works by boosting norepinephrine and dopamine by blocking the norepinephrine reuptake pump and dopamine reuptake pump (Stahl, 2017). Bupropion inhibits CYP450 2D6, has a parent half-life of 10-14 hours, and a metabolite half-life of 20-27 hours (Stahl, 2017). Thus, since bupropion blocks the dopamine reuptake pump and norepinephrine reuptake pump, this medication is beneficial in improving symptoms of loss of happiness, joy, interest, pleasure, energy, enthusiasm, alertness, and self-confidence (Stahl, 2013). Thus, because of bupropion’s mechanism of action and the patient’s symptoms, I would want this patient to try this medication.
Lessons Learned
Lessons learned during this case study is that geriatric depression can be difficult to treat. They often have multiple comorbidities with the possibility of more pronounced side-effects (Stahl, 2008). Additionally, medications can have contraindications that do not previously exist prior to the patient being put on medication. Thus, providers must be aware of new and old warnings on medications in the event there are changes made to medications. I will apply this information when I am in practice by paying close attention to dosages, side effects, and potential contraindications when providing medication to the geriatric population.
References
American Psychiatric Association. (2013). Diagnostic and statistical manual od mental disorders (5th ed.). Washington, DC: Author. Centers for Disease Control and Prevention. (2016). Tips for better sleep. Retrieved from https://www.cdc.gov/sleep/about_sleep/sleep_hygiene.htmlNa, P. J., Yaramala, S. R., Kim, J. A., Kim, H., Goes, F. S., Zandi, P. P.,…Bobo, W. V. (2018). The PHQ-9 item 9 based screening for suicide risk: a validation study of the Patient Health Questionnaire (PHQ-9)-9 item 9 with the Columbia Suicide Severity Rating Scale (C-SSRS). Journal of Affective Disorders, 232, 34-40. doi: https://doi.org/10.1016/j.jad.2018.02.045National Sleep Foundation. (n.d.). Sleep apnea. Retrieved from https://www.sleepfoundation.org/sleep-apneaThis Way Up. (n.d.). How do you feel? Retrieved from https://thiswayup.org.au/how-do-you-feel/sad/Stahl, S. M. (2008). Essential psychopharmacology online. Retrieved from https://stahlonline-cambridge-org.ezp.waldenulibrary.org/viewPdf?page=csEP_16.pdf&vol=2Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY: Cambridge University Press. Stahl, S. (2017). Stahl’s essential psychopharmacology: Prescriber’s guide (6th ed.). San Diego, CA: Cambridge University Press.
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Post A Description Of The Interview And Communication Techniques You Would Use With Your Selected Patient Explain Why You Would Use These Techniques Identify The Risk Assessment Instrument You Selected And Justify Wh
/in Uncategorized /by developerPost a description of the interview and communication techniques you would use with your selected patient. Explain why you would use these techniques. Identify the risk assessment instrument you selected, and justify why it would be applicable to the selected patient. Provide at least five targeted questions you would ask the patient.
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Post A Short Reflection Approximately 1 Paragraph In Length Discussing Your Thoughts And Opinions About One Or Several Of The Specific Theories Covered In The Readings Chapters 21 And 22 2 References
/in Uncategorized /by developerText and materials:
Ruth M. Tappen. (2015). Nursing Research. Advanced Nursing Research: From Theory to Practice. (2nd ed.). ISBN-13: 9781284048308. ISBN-10: 1284048306. Publisher: Jones & Bartlett Learning
Section VI: Middle Range Theories
Chapter 21: Katharine Kolcaba’s Comfort Theory
Chapter 22: Joanne Duffy’s Quality-Caring Model
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Post A Short Reflection Approximately 1 Paragraph In Length
/in Uncategorized /by developerComplete this week’s assigned readings, chapters 59,68,70.After completing the readings, post a short reflection, approximately 1 paragraph in length, discussing your thoughts and/or professional concerns about one or several of the specific topics covered in the textbook readings. pertaining to health policy and politics. Identify which one MSN Essential most relates to your selected topic in your discussion
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Post Abby Ebp
/in Uncategorized /by developerRespond using one or more of the following approaches:
Ask a probing question, substantiated with additional background information, and evidence
Offer and support an alternative perspective using readings from the classroom or from your own review of the literature in the Walden Library.
Make a suggestion based on additional evidence drawn from readings or after synthesizing multiple postings.
Reference:
Skloot, R. (2010). The immortal life of Henrietta Lacks. New York, NY: Crown Publishing Group.
MAIN POST
Ethical Dimensions of Research Studies
Nursing research and research studies can offer many gains in the healthcare field and offer clear, conscience evidenced-based practices (EBP). Before diving into conducting a research study it is essential to understand ethical issues and ethical dilemmas. Research ethics demand necessity on daily work, the protection of test subject’s and the publicizing of information from the research (Fouka & Mantzorou, 2011). Ethical dilemmas are situations where the test subject’s rights are in conflict with the studies requirements (Polit & Beck, 2017). Nursing researcher need to be aware of any ethical issues and develop a research plan to help alleviate any problems or ethical dilemmas.
Transfusion of Prematures
Transfusion of Prematures (TOP) Trial was an open, parallel-group multicenter randomized controlled trial (RCT) analyzed by the intention to treat (Kirpalani et al., 2012). The main point of the TOP trial was to determine whether higher hemoglobin levels for giving transfusions to extremely low birth weight infants could result in higher hemoglobin levels leading to the improvements in neurodevelopmental impairment at 22-26 months of age and the primary outcome to be survival (ClinicalTrials, 2019). The trial explained that by avoiding a breach the current practice boundaries of the hemoglobin levels that would require an infusion by using a transfusion algorithm. This would avoid dilemmas and minimize risks to the test subject’s. There are no real results of this trial. The test subject’s will be seen for follow-up visits at around six years old to assess neurological and functional outcomes based on the transfusion threshold (Kirpaplani et al., 2012).
Ethical Principles
Three principles that standards of ethical conduct in research are based on are beneficence, respect for human dignity and justice (Polit & Beck, 2017). Beneficence can be explained as a duty to promote good and eliminate harm to the test subjects. The TOP trial was seen by the Institutional Review Board (IRB) as harmful by veering away from usual care and harmful risks were posed by the deviations (National Public Radio, 2013). The researcher could have maintained usual care and not deviate from routine care on the test subjects. The second ethical principle is respect for human dignity which is the right to know what will take place or full disclosure (Polit & Beck, 2017). The TOPS trial had defects and faced criticism for not telling all this risks that the subjects would face. In this trial the consent forms did not elaborate on previous studies about when to transfuse. The studies suggested that premature infants that had transfusions later had a higher chance of death, brain injury and emergency care for transfusions (National Public Radio, 2013). The researchers should have been honest to the test subject’s parents regarding the previous studies and the risks of participation in the study. The third principle is justice which allows for fair treatment and the right to have privacy (Polit & Beck, 2017). In the TOPS trial it was suggested that the subject’s parents were not aware of what was being asked. Parents were giving up their rights to a physician to make decisions on what they feel was in the best interest of the infant. This would impede on the right to fair treatment. The researchers need to make sure that the parents of the test subjects understand every aspect of the trial and have the rights to make decisions on what they feel is in the best interest of their child. The parent should have the say so in what is being done to their child and not a physician. Research can be done on sensitive issues while protecting the rights of the research subjects by following the ethical principles. Adopting the ethical principles will help avoid ethical dilemmas in research.
Conclusion
Nursing research has many benefits to the practice and can produce evidence- based practices to help provide the best care to our patients. Ethical dilemmas can be avoided by conducting a study that poses minimal conflicts with patient rights. Making patient safety the main goal is essential in the success of a research study. Keeping ethical principles of beneficence, respect for human dignity, and justice intertwined in the development or framework of the study is the only way to ensure that participants are being protected.
References
ClinicalTrials. (2019). Transfusion of Prematures (TOP). Retrieved March 18, 2019, from http://www.clinicaltrials.gov/ct2/show/NCT01702805.
Fouka, G., & Mantzorou, M. (2011). What are the major ethical issues in conducting research? Is there a conflict between the research ethics and the nature of nursing? Health Science Journal, 5(1), 3-14. Retrieved from the Walden Library databases.
Kirpalani, H., Bell, H., D’Angio, C., Hintz, S., Kennedy, K., Ohls, R., Poindexter, B., Schibler, K., Schmidt, B., Vohr, B., Widness, J., Das, A., Higgins, R., Zupancic, J., Roberts, R., Whyte, R., Chaudhary, A., & Johnson, K. (2012). Transfusion of Prematures (TOP) Trial: Does a Liberal Red Blood Cell Transfusion Strategy Improve Neurologically-Intact Survival of Extremely-Low-Birth-Weight Infants as Compared to a Restrictive Strategy? Neonatal Research Network. Retrieved from http://www.nichd.nih.gov/sites/default/files/about/Documents/ TOP_Protocol.pdf.
National Public Radio (2013). Another Study of Preemies Blasted Over Ethical Concerns. Retrieved March 18, 2019, from http://www.npr.org/sections/health-shots/2013/08/23/214800726/another-study-of-preemies-blasted-over-ethical-concerns.
Polit, D.F., & Beck, C.T. (2017) Nursing Research Generating and Assessing Evidence for Nursing Practice (10th ed.). Philadelphia, PA: Wolters Kluwer.
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Post Abby Pharmacology
/in Uncategorized /by developerRead a selection of your colleagues’ responses and respond to at least two of your colleagues on two different days who selected a different interactive media piece on a psychological disorder, and provide recommendations for alternative drug treatments to address the patient’s pathophysiology.
Main Post
Depression Scenario
The interactive depression scenario described a 70-year-old male who presented with complaints of depression (Laureate Education, 2019). He also reported shoulder pain related to warehouse labor, experiencing the death of his mother at a young age, being an outsider at school, anhedonia, recent weight gain, insomnia, and poor concentration (Laureate Education, 2019). On exam, he had poor eye contact, soft speech, constricted affect without evidence of psychosis or suicidal/homicidal ideation (Laureate Education, 2019). For the first decision, I chose to start the patient on Zoloft 25 mg oral daily. When the patient returned four weeks later with a 25 percent improvement of depressive symptoms and a new onset of erectile dysfunction, I chose to add Wellbutrin IR 150 mg in the morning. When the patient came in four weeks later with the continued decrease of depressive symptoms, no erectile dysfunction, and feelings of increased nervousness, I chose to change the Wellbutrin order to Wellbutrin XL 150 mg oral in the morning.
Pharmacotherapeutic Impact on Pathophysiology
When choosing initial treatment options for depression, the classes of medications have similar efficacy, so it is best to focus on safety and medication tolerance (Rosenthal & Burchum, 2018). Therefore, I chose to start with a Selective Serotonin Reuptake Inhibitor (SSRI), recognized as the safest and most tolerated medications for treating major depression (Rosenthal & Burchum, 2018). The pathophysiology of these medications is unclear; however, the theory suggests that these medications compensate for serotonin deficiency in the synapse (Holck, Wolkowitz, Mellon, Reus, Nelson, Westrin, & Lindqvist, 2019). Serotonin is needed to regulate sleep, mood, and cognition (Holck et al., 2019). By increasing the amount of Serotonin in the synapse, this patient’s depressive symptoms decreased. In the second decision, I chose to add Wellbutrin IR to the patient’s medication regimen to help treat his erectile dysfunction symptoms. Wellbutrin is an atypical antidepressant where the mechanism of action is also not understood (Rosenthal & Burchum, 2018). However, the effects may be related to blocking the reuptake of dopamine, which regulates behavior and influences learning, and norepinephrine, which plays a role in getting the brain and body ready for action (Berke, 2018; Rosenthal & Burchum, 2018). While Wellbutrin helps depression, it also seems to help with sexual desire (Rosenthal & Burchum, 2018). Fortunately, this additional medication helped the patient in the scenario. After four weeks of taking both drugs, he had a continued decrease in depressive symptoms and no longer struggled with sexual dysfunction. In my third decision, I chose to change the Wellbutrin order to extended-release since the patient was experiencing restlessness symptoms. The immediate-release may have been too much, too fast for the patient as it reaches its peak two hours after administration (Rosenthal & Burchum, 2018). Extended-release Wellbutrin reaches its peak at five hours with a half-life of approximately 21 hours (Food and Drug Administration, n.d.). This change will help to settle the experienced side effects of the medication.
Treatment Plan The effect of Zoloft and Wellbutrin on the patient’s pathophysiology will impact the patient’s treatment plan. Common side effects of SSRIs include weight gain, insomnia, sexual dysfunction, and increased risk of suicide (Rosenthal & Burchum, 2018). I already addressed sexual dysfunction by adding Wellbutrin, but the monitoring for the other side effects is also essential for safety and compliance purposes. The patient already has had a significant amount of weight gain and complains about insomnia. Therefore, follow up appointments are necessary for close monitoring of these possible side effects. Treatment should include education about proper diet and activity to regulate weight. The provider should also assess the patient’s sleep to ensure the medication is helping rather than worsening the amount and quality of sleep. It is also crucial for the provider to educate the patient on the increased risk of suicide and encourage the patient to seek help immediately if he starts having these thoughts. The provider should assess the patient for suicidal ideation frequently.
Wellbutrin is usually well tolerated; however, it carries a risk for seizures and psychotic symptoms. Therefore, the provider should assess for any seizure risk factors such as a history of seizures, a head injury, an eating disorder, or a CNS tumor (Rosenthal & Burchum, 2018). The provider should also assess the patient for psychotic symptoms at each follow-up visit, such as hallucinations or delusional thoughts (Rosenthal & Burchum, 2018).
References
Berke, J.D. (2018). What does dopamine mean? Nature Neuroscience, 21(6), 787-793. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29760524Food and Drug Administration. (n.d.). Wellbutrin XL. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021515s026s027lbl.pdfHolck, A., Wolkowitz, O. M., Mellon, S. H., Reus, V. I., Nelson, J. C., Westrin, Å., & Lindqvist, D. (2019). Plasma serotonin levels are associated with antidepressant response to SSRIs. Journal of Affective Disorders, 250, 65–70. https://doi-org.ezp.waldenulibrary.org/10.1016/j.jad.2019.02.063Laureate Education (Producer). (2019). Adult geriatric depression [Interactive media file]. Baltimore, MD: Author.Rosenthal, L. D., & Burchum, J. R. (2018). Lehne’s pharmacotherapeutics for advanced practice providers. St. Louis, MO: Elsevier.
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